Title:
COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER
Document Type and Number:
WIPO Patent Application WO2001096389
Kind Code:
A3
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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Inventors:
MEAGHER MADELEINE JOY (US)
KING GORDON E (US)
XU JIANGCHUN (US)
SECRIST HEATHER (US)
KING GORDON E (US)
XU JIANGCHUN (US)
SECRIST HEATHER (US)
Application Number:
PCT/US2001/018574
Publication Date:
June 19, 2003
Filing Date:
June 07, 2001
Export Citation:
Assignee:
CORIXA CORP (US)
MEAGHER MADELEINE JOY (US)
KING GORDON E (US)
XU JIANGCHUN (US)
SECRIST HEATHER (US)
MEAGHER MADELEINE JOY (US)
KING GORDON E (US)
XU JIANGCHUN (US)
SECRIST HEATHER (US)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C12N15/12; A61K31/7088; A61K38/17; C07K14/47; C07K14/81; C07K16/18; C12N5/06; C12N15/11; C12N15/62; C12Q1/68; G01N33/50
Domestic Patent References:
| WO1999047674A2 | 1999-09-23 | |||
| WO2002002623A2 | 2002-01-10 | |||
| WO2000055351A1 | 2000-09-21 | |||
| WO2001036674A2 | 2001-05-25 |
Other References:
DATABASE EM_EST EBI Hinxton, UK; 13 July 1999 (1999-07-13), NCI-CGAP: "Homo sapiens cDNA clone IMAGE:2406189", XP002192540
PENNACCHIO LEN A ET AL: "Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).", SCIENCE (WASHINGTON D C), vol. 271, no. 5256, 1996, pages 1731 - 1734, XP002192539, ISSN: 0036-8075
J-M FRIGERIO ET AL: "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 4, no. 1, 1995, pages 37 - 43, XP002111970, ISSN: 0964-6906
YEATMAN T J AND MAO W: "Identification of a differentially-expressed message associated with colon cancer liver metastasis using an improved method of differential display", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 19, 1995, pages 4007 - 4008, XP002099962, ISSN: 0305-1048
CHAN E-C ET AL: "Identification of novel genes that are differentially expressed in human colorectal carcinoma", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1407, no. 3, 30 September 1998 (1998-09-30), pages 200 - 204, XP000910494, ISSN: 0006-3002
MEAGHER M J ET AL.: "Identification of differentially expressed genes in colon tumors using cDNA subtraction and microarray analysis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 173, XP001064177, ISSN: 0197-016X
PENNACCHIO LEN A ET AL: "Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).", SCIENCE (WASHINGTON D C), vol. 271, no. 5256, 1996, pages 1731 - 1734, XP002192539, ISSN: 0036-8075
J-M FRIGERIO ET AL: "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 4, no. 1, 1995, pages 37 - 43, XP002111970, ISSN: 0964-6906
YEATMAN T J AND MAO W: "Identification of a differentially-expressed message associated with colon cancer liver metastasis using an improved method of differential display", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 19, 1995, pages 4007 - 4008, XP002099962, ISSN: 0305-1048
CHAN E-C ET AL: "Identification of novel genes that are differentially expressed in human colorectal carcinoma", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1407, no. 3, 30 September 1998 (1998-09-30), pages 200 - 204, XP000910494, ISSN: 0006-3002
MEAGHER M J ET AL.: "Identification of differentially expressed genes in colon tumors using cDNA subtraction and microarray analysis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 173, XP001064177, ISSN: 0197-016X
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