Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A CD8 ENGINEERED T CELL THERAPY
Document Type and Number:
WIPO Patent Application WO/2020/223537
Kind Code:
A8
Abstract:
Compositions comprising and methods for the treatment of cancer using a neoTCR based cell therapy with a CD8 expression construct. In certain embodiments, the presently disclosed subject matter provides a cell, comprising an exogenous T cell receptor (TCR), and an exogenous CD8. In certain embodiments, the exogenous CD8 comprises at least one monomer. In certain embodiments, the at least one monomer of the exogenous CD8 comprises an extracellular domain, a transmembrane domain, an intracellular domain, fragments thereof, or combinations thereof.
Inventors:
SENNINO BARBARA (US)
JACOBY KYLE (US)
MANDL-CASHMAN STEFANIE (US)
DUBREUIL MICHAEL (US)
GAGNON JOHN (US)
FRANZUSOFF ALEX (US)
JACOBY KYLE (US)
MANDL-CASHMAN STEFANIE (US)
DUBREUIL MICHAEL (US)
GAGNON JOHN (US)
FRANZUSOFF ALEX (US)
Application Number:
PCT/US2020/030818
Publication Date:
November 11, 2021
Filing Date:
April 30, 2020
Export Citation:
Assignee:
PACT PHARMA INC (US)
International Classes:
C07K14/725; C07K14/73; C07K16/28; C07K16/32; C12N5/0783
Attorney, Agent or Firm:
LENDARIS, Steven, P. et al. (US)
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