Title:
COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/023844
Kind Code:
A1
Abstract:
A compound useful as, e.g., a surface modifier for use in producing, e.g., a drug carrier, or a salt of the compound; and fine particles containing either of these. The compound is one obtained by modifying a substance to be modified which is selected from the group consisting of amphiphatic substances and hydrophobic substances with a glycerol derivative represented by the formula (1) (wherein R represents a residue which comprises a group reactive with either the substance to be modified, which is selected from the group consisting of amphiphatic substances and hydrophobic substances, or a spacer for bonding the substance to be modified, which is selected from the group consisting of amphiphatic substances and hydrophobic substances, to R-X or comprises a group capable of being converted to the reactive group; n is an integer of 3 or larger; and X represents a residue capable of having n groups of the following formula) directly or through the spacer.
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Inventors:
NEMOTO HISAO (JP)
YAMAUCHI MASAHIRO (JP)
KUSANO HIROKO (JP)
KATO YASUKI (JP)
YAMASAKI MOTOO (JP)
SUZAWA TOSHIYUKI (JP)
YAMAUCHI MASAHIRO (JP)
KUSANO HIROKO (JP)
KATO YASUKI (JP)
YAMASAKI MOTOO (JP)
SUZAWA TOSHIYUKI (JP)
Application Number:
PCT/JP2004/013187
Publication Date:
March 17, 2005
Filing Date:
September 03, 2004
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
TECNO NETWORK SHIKOKU CO LTD (JP)
NEMOTO HISAO (JP)
YAMAUCHI MASAHIRO (JP)
KUSANO HIROKO (JP)
KATO YASUKI (JP)
YAMASAKI MOTOO (JP)
SUZAWA TOSHIYUKI (JP)
TECNO NETWORK SHIKOKU CO LTD (JP)
NEMOTO HISAO (JP)
YAMAUCHI MASAHIRO (JP)
KUSANO HIROKO (JP)
KATO YASUKI (JP)
YAMASAKI MOTOO (JP)
SUZAWA TOSHIYUKI (JP)
International Classes:
A61K47/00; A61K47/48; C07C323/60; C07F9/10; C07K5/02; (IPC1-7): C07K5/08; C07C233/47; C07C323/52; C07D207/404; A61K9/107; A61K9/127; A61K47/42
Domestic Patent References:
| WO2004029018A1 | 2004-04-08 |
Foreign References:
| JPH08325271A | 1996-12-10 |
Other References:
CASSEL, S. ET AL.: "Original synthesis of linear, branched and cyclic oligoglycerol standards", EUR.J.ORG.CHEM., vol. 5, 2001, pages 875 - 896, XP002983658
ZHONG, J.H. ET AL.: "Photochemistry on Soluble Polymer Supports: Synthesis of Nucleosides", ORGANIC LETTERS, vol. 4, no. 25, 2002, pages 4415 - 4417, XP002983659
DAS, B.C. ET AL.: "Synthesisof a water soluble boron neutron capture therapy agent: 1-amino-3-[2-(7-{3-[2-(2-hydroxymethyl-ethoxy)-1-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)ethoxy]propyl}-1, 7-di-carba-closo-dodecaboran-1-yl)ethyl]cyclobutanecarboxylic acid", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 614-615, 2000, pages 255 - 261, XP004227432
NEMOTO, H. ET AL.: "Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 2, 1999, pages 205 - 208, XP004152601
See also references of EP 1666486A4
ZHONG, J.H. ET AL.: "Photochemistry on Soluble Polymer Supports: Synthesis of Nucleosides", ORGANIC LETTERS, vol. 4, no. 25, 2002, pages 4415 - 4417, XP002983659
DAS, B.C. ET AL.: "Synthesisof a water soluble boron neutron capture therapy agent: 1-amino-3-[2-(7-{3-[2-(2-hydroxymethyl-ethoxy)-1-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)ethoxy]propyl}-1, 7-di-carba-closo-dodecaboran-1-yl)ethyl]cyclobutanecarboxylic acid", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 614-615, 2000, pages 255 - 261, XP004227432
NEMOTO, H. ET AL.: "Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 2, 1999, pages 205 - 208, XP004152601
See also references of EP 1666486A4
Attorney, Agent or Firm:
Oguri, Shohei (13th Floor ARK Mori Building, 12-32, Akasaka 1-chom, Minato-ku Tokyo, JP)
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