Title:
COMPOUND REPRESENTED BY FORMULA I AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/061791
Kind Code:
A1
Abstract:
Disclosed in the invention are a compound and a use thereof. The compound is a compound represented by formula I or a stereoscopic isomer, a racemate, an oxynitride, a hydrate, a metabolite, a pharmaceutically acceptable salt or prodrug of the compound represented by formula I, wherein R1, R2 and R3 are each independently -H, -OCH3, -F, Cl, -Br; X is -CN or -COOCH2CH3; and A is a linear fused ring or an angular fused ring. The compound represented by formula I is simple in structure and easy to prepare, relative to a pilot tubulin inhibitor mHA11, the compound is more efficient and less toxic and can effectively inhibit the normal functions of tumor cell tubulin, induce tumor cell apoptosis, and at the same time target and interfere with tumor angiogenesis.
Inventors:
HUANG ZIWEI (CN)
FANG XIONG (CN)
ZHANG HUIJUN (CN)
XU YAN (CN)
AN JING (CN)
FANG XIONG (CN)
ZHANG HUIJUN (CN)
XU YAN (CN)
AN JING (CN)
Application Number:
PCT/CN2017/113619
Publication Date:
April 04, 2019
Filing Date:
November 29, 2017
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07D491/052; A61K31/357; A61K31/407; A61K31/4188; A61K31/436; A61K31/5383; A61K45/06; A61P35/00; A61P35/02; C07D493/04; C07D498/04
Domestic Patent References:
| WO2002092083A1 | 2002-11-21 |
Foreign References:
| CN103328463A | 2013-09-25 |
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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