Title:
CONCOMITANT DRUGS FOR PREVENTING OR TREATING INFECTION WITH GRAM-POSITIVE BACTERIA
Document Type and Number:
WIPO Patent Application WO/2000/057882
Kind Code:
A1
Abstract:
Concomitant drugs for preventing or treating infection with gram-positive bacteria characterized in that at least one $g(b)-lactam antimicrobial having an inhibitory effect on $i(Staphylococcus) and at least one antimicrobial selected from among tetracycline antimicrobials, quinolone antimicrobials, amino glycoside antimicrobials, macrolide antimicrobials and steroid antimicrobials are administered either simultaneously or separately at an interval.
Inventors:
YOKOTA YOSHIKO (JP)
Application Number:
PCT/JP2000/001602
Publication Date:
October 05, 2000
Filing Date:
March 16, 2000
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
YOKOTA YOSHIKO (JP)
YOKOTA YOSHIKO (JP)
International Classes:
A61K31/00; A61K31/43; A61K31/431; A61K31/535; A61K31/5375; A61K31/5383; A61K31/545; A61K31/546; A61K31/65; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61K31/7042; A61K31/7048; A61K45/06; A61P31/00; A61P31/04; (IPC1-7): A61K31/545; A61K31/575; A61K31/65; A61K31/7008; A61P31/04
Other References:
KOBAYASHI, SHINZO ET. AL.: "In vitro and in vivo effects of combinations of cefotaxime or other beta-lactams with rolitetracycline on methicillin-resistant Staphylococcus aureus", JPN. J. ANTIBIOT, vol. 42, no. 5, 1989, pages 1208 - 1215, XP002928790
DASCHNER, FRANZ D: "Combination of bacteriostatic and bactericidal drugs: lack of significant in vitro antagonism between penicillin, cephalothin, and rolitetracyline", ANTIMICROB. AGENTS CHEMOTHER, vol. 10, no. 5, 1976, pages 802 - 808, XP002928791
ERSKINE R. J. ET. AL.: "Efficacy of intramuscular oxytetracyline as a dry cow treatment for Staphylococcus aureus mastitis", J. DAIRY SCI., vol. 77, no. 11, 1994, pages 3347 - 3353, XP002928792
MARCHESE, ANNA ET. AL.: "Antistaphylococcal activity of cefdinir, a new oral third-generation cephalosporin, alone and in combination with other antibiotics, at supra- and sub-MIC levels", J. ANTIMICROB. CHEMOTHER, vol. 35, no. 1, 1995, pages 53 - 66, XP002928793
NIX, DAVID E. ET. AL.: "Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics", DIAGN. MICROBIOL. INFECT. DIS., vol. 22, no. 1-2, 1995, pages 71 - 76, XP002928794
JUST, H. M. ET. AL.: "In vitro combination effects of cefotetan with four aminoglycosides, piperacillin and mezlocillin on gram-positive and gram-negative nosocomial bacteria", CHEMOTHERAPY (BASEL), vol. 30, no. 6, 1984, pages 387 - 391, XP002928795
THABAUT, A. ET. AL.: "Etude in vitro de 1'effect bactericide des associations du cefotetan aux aminosides", PATHOLOGIE BIOLOGIE, vol. 36, no. 5, 1988, pages 361 - 365, XP002928796
OTTEN, H.: "Experimental study on erythromycin in combination with beta-lactam and aminoglycoside antibiotics", INFECTION (MUNICH), vol. 8, no. 3, 1980, pages 310 - 312, XP002928797
CHEMICAL ABSTRACTS, vol. 123, 17 July 1995, Columbus, Ohio, US; abstract no. 29399, RHEE, JOON HAENG ET. AL.: "In vitro combined effect of cefamandole with other antimicrobial agents against methicillin-resistant staphylococci" page 474; column 1;
DASCHNER, FRANZ D: "Combination of bacteriostatic and bactericidal drugs: lack of significant in vitro antagonism between penicillin, cephalothin, and rolitetracyline", ANTIMICROB. AGENTS CHEMOTHER, vol. 10, no. 5, 1976, pages 802 - 808, XP002928791
ERSKINE R. J. ET. AL.: "Efficacy of intramuscular oxytetracyline as a dry cow treatment for Staphylococcus aureus mastitis", J. DAIRY SCI., vol. 77, no. 11, 1994, pages 3347 - 3353, XP002928792
MARCHESE, ANNA ET. AL.: "Antistaphylococcal activity of cefdinir, a new oral third-generation cephalosporin, alone and in combination with other antibiotics, at supra- and sub-MIC levels", J. ANTIMICROB. CHEMOTHER, vol. 35, no. 1, 1995, pages 53 - 66, XP002928793
NIX, DAVID E. ET. AL.: "Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics", DIAGN. MICROBIOL. INFECT. DIS., vol. 22, no. 1-2, 1995, pages 71 - 76, XP002928794
JUST, H. M. ET. AL.: "In vitro combination effects of cefotetan with four aminoglycosides, piperacillin and mezlocillin on gram-positive and gram-negative nosocomial bacteria", CHEMOTHERAPY (BASEL), vol. 30, no. 6, 1984, pages 387 - 391, XP002928795
THABAUT, A. ET. AL.: "Etude in vitro de 1'effect bactericide des associations du cefotetan aux aminosides", PATHOLOGIE BIOLOGIE, vol. 36, no. 5, 1988, pages 361 - 365, XP002928796
OTTEN, H.: "Experimental study on erythromycin in combination with beta-lactam and aminoglycoside antibiotics", INFECTION (MUNICH), vol. 8, no. 3, 1980, pages 310 - 312, XP002928797
CHEMICAL ABSTRACTS, vol. 123, 17 July 1995, Columbus, Ohio, US; abstract no. 29399, RHEE, JOON HAENG ET. AL.: "In vitro combined effect of cefamandole with other antimicrobial agents against methicillin-resistant staphylococci" page 474; column 1;
Attorney, Agent or Firm:
Tabushi, Eiji (Ltd. Osaka Factory 1-6 Kashima 2-chome Yodogawa-ku, Osaka-shi Osaka, JP)
Download PDF: