Title:
CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/201203
Kind Code:
A3
Abstract:
The present disclosure provides Type VI CRISPR-Cas effector polypeptides that can, when complexed with a guide nucleic acid, modify a target RNA. A Type VI CRISPR-Cas effector polypeptide of the present disclosure can also provide for detection of nucleic acid by cleavage of non-target RNAs. The present disclosure provides methods of modifying a target RNA, and methods of detecting a nucleic acid.
Inventors:
BANFIELD JILLIAN F (US)
AL-SHAYEB BASEM (US)
DOUDNA JENNIFER A (US)
AL-SHAYEB BASEM (US)
DOUDNA JENNIFER A (US)
Application Number:
PCT/US2023/065592
Publication Date:
February 01, 2024
Filing Date:
April 10, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
BANFIELD JILLIAN F (US)
BANFIELD JILLIAN F (US)
International Classes:
C12N15/10; C12N15/11; C12N15/113; C12N15/90; C12N9/22; C12N9/78
Domestic Patent References:
| WO2021055874A1 | 2021-03-25 |
Foreign References:
| US11225659B2 | 2022-01-18 | |||
| US20230025039A1 | 2023-01-26 |
Attorney, Agent or Firm:
BORDEN, Paula A. (US)
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