Title:
CRYSTALLINE FORMS AND SALTS OF A PI3K INHIBITOR AND METHODS OF MAKING AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/179771
Kind Code:
A1
Abstract:
Provided herein are salts and crystalline forms of Compound (I), and salts, solvates, and salt solvates thereof. Also provided herein are pharmaceutical compositions comprising the crystalline forms, and therapeutic uses of the crystalline forms and the compositions thereof.
Inventors:
DHAWAN NEIL SONIN (US)
BLAIR JAMES ABELLERA (US)
PERNI ROBERT B (US)
RANDALL JARED LYNN (US)
WANG XIAOYANG (CN)
LI MEIQI (CN)
BLAIR JAMES ABELLERA (US)
PERNI ROBERT B (US)
RANDALL JARED LYNN (US)
WANG XIAOYANG (CN)
LI MEIQI (CN)
Application Number:
PCT/CN2023/083760
Publication Date:
September 28, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
TOTUS MEDICINES INC (US)
DHAWAN NEIL SONIN (US)
BLAIR JAMES ABELLERA (US)
PERNI ROBERT B (US)
RANDALL JARED LYNN (US)
WANG XIAOYANG (CN)
DHAWAN NEIL SONIN (US)
BLAIR JAMES ABELLERA (US)
PERNI ROBERT B (US)
RANDALL JARED LYNN (US)
WANG XIAOYANG (CN)
International Classes:
A61K31/519; C07D487/04; A61P35/00; C07C55/10; C07C57/145; C07C57/15; C07C59/255; C07C59/265; C07C309/04; C07C309/29; C07C309/30
Domestic Patent References:
| WO2021055747A1 | 2021-03-25 | |||
| WO2021055747A1 | 2021-03-25 |
Other References:
HARWOOD: "Experimental organic chemistry - Principles and practice", 1989, BLACKWELL SCIENCE, Oxford, ISBN: 978-0-632-02016-4, pages: 127 - 132, XP003025361
ANDERSON: "Practical Process Research & Development, Chapter 11, Tools for Purifying the Product: Column Chromatography, Crystallization and Reslurrying", 2000, ACADEMIC PRESS, San Diego, ISBN: 978-0-12-059475-7, pages: 223 - 224, XP002565895
CAIRA: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, vol. 198, 1998, pages 163 - 208, XP001156954, ISSN: 0340-1022, [retrieved on 19990226], DOI: 10.1007/3-540-69178-2_5
BYRN ET AL.: "Pharmaceutical Solids: A strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, July 1995 (1995-07-01), pages 945 - 954, XP000996386, ISSN: 0724-8741, DOI: 10.1023/A:1016241927429
VANHAESEBROECK ET AL., ANNU. REV. BIOCHEM, vol. 70, 2001, pages 535
KATSO ET AL., ANNU. REV. CELL DEV. BIOL., vol. 17, 2001, pages 615
CANTLEY ET AL., CELL, vol. 64, 1991, pages 281
ESCOBEDOWILLIAMS, NATURE, vol. 335, 1988, pages 85
FANTL ET AL., CELL, vol. 69, 1992, pages 413
"Remington: The Science and Practice of Pharmacy", LIPPINCOTT, WILLIAMS & WILKINS
ANDERSON: "Practical Process Research & Development, Chapter 11, Tools for Purifying the Product: Column Chromatography, Crystallization and Reslurrying", 2000, ACADEMIC PRESS, San Diego, ISBN: 978-0-12-059475-7, pages: 223 - 224, XP002565895
CAIRA: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, vol. 198, 1998, pages 163 - 208, XP001156954, ISSN: 0340-1022, [retrieved on 19990226], DOI: 10.1007/3-540-69178-2_5
BYRN ET AL.: "Pharmaceutical Solids: A strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, July 1995 (1995-07-01), pages 945 - 954, XP000996386, ISSN: 0724-8741, DOI: 10.1023/A:1016241927429
VANHAESEBROECK ET AL., ANNU. REV. BIOCHEM, vol. 70, 2001, pages 535
KATSO ET AL., ANNU. REV. CELL DEV. BIOL., vol. 17, 2001, pages 615
CANTLEY ET AL., CELL, vol. 64, 1991, pages 281
ESCOBEDOWILLIAMS, NATURE, vol. 335, 1988, pages 85
FANTL ET AL., CELL, vol. 69, 1992, pages 413
"Remington: The Science and Practice of Pharmacy", LIPPINCOTT, WILLIAMS & WILKINS
Attorney, Agent or Firm:
WU , FENG & ZHANG (CN)
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