Title:
CRYSTALLIZATION AND STRUCTURE OF PEPTIDE DEFORMYLASE
Document Type and Number:
WIPO Patent Application WO2002002758
Kind Code:
A3
Abstract:
Staphylococcus aureus peptide deformylase has been crystallized, and the three-dimensional x-ray crystal structure has been solved to 1.9 ANGSTROM resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing modifiers of peptide deformylase activity.
Inventors:
BALDWIN ERIC T (US)
HARRIS MELISSA S (US)
HARRIS MELISSA S (US)
Application Number:
PCT/US2001/020777
Publication Date:
August 29, 2002
Filing Date:
June 29, 2001
Export Citation:
Assignee:
UPJOHN CO (US)
BALDWIN ERIC T (US)
HARRIS MELISSA S (US)
BALDWIN ERIC T (US)
HARRIS MELISSA S (US)
International Classes:
C12N9/80; (IPC1-7): C12N9/80; C12Q1/34; G06F17/50
Foreign References:
| EP0879879A2 | 1998-11-25 |
Other References:
JANCARIK J ET AL: "SPARSE MATRIX SAMPLING: A SCREENING METHOD FOR CRYSTALLIZATION OF PROTEINS", JOURNAL OF APPLIED CRYSTALLOGRAPHY, COPENHAGEN, DK, vol. 24, 1991, pages 409 - 411, XP001053042, ISSN: 0021-8898
HUNTINGTON KRISTI M ET AL: "Synthesis and antibacterial activity of peptide deformylase inhibitors.", BIOCHEMISTRY, vol. 39, no. 15, 18 April 2000 (2000-04-18), pages 4543 - 4551, XP002202850, ISSN: 0006-2960
HAO BING ET AL: "Structural basis for the design of antibiotics targeting peptide deformylase.", BIOCHEMISTRY, vol. 38, no. 15, 13 April 1999 (1999-04-13), pages 4712 - 4719, XP002202851, ISSN: 0006-2960
GREER J: "PROTEIN STRUCTURE AND FUNCTION BY COMPARATIVE MODEL BUILDING", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 439, 1985, pages 44 - 63, XP001053165, ISSN: 0077-8923
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
CHEN DAWN Z ET AL: "Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.", BIOCHEMISTRY, vol. 39, no. 6, 15 February 2000 (2000-02-15), pages 1256 - 1262, XP002202852, ISSN: 0006-2960
HUNTINGTON KRISTI M ET AL: "Synthesis and antibacterial activity of peptide deformylase inhibitors.", BIOCHEMISTRY, vol. 39, no. 15, 18 April 2000 (2000-04-18), pages 4543 - 4551, XP002202850, ISSN: 0006-2960
HAO BING ET AL: "Structural basis for the design of antibiotics targeting peptide deformylase.", BIOCHEMISTRY, vol. 38, no. 15, 13 April 1999 (1999-04-13), pages 4712 - 4719, XP002202851, ISSN: 0006-2960
GREER J: "PROTEIN STRUCTURE AND FUNCTION BY COMPARATIVE MODEL BUILDING", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 439, 1985, pages 44 - 63, XP001053165, ISSN: 0077-8923
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
CHEN DAWN Z ET AL: "Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.", BIOCHEMISTRY, vol. 39, no. 6, 15 February 2000 (2000-02-15), pages 1256 - 1262, XP002202852, ISSN: 0006-2960
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