DELIVERY OF A BIOACTIVE MATERIAL

Title:

DELIVERY OF A BIOACTIVE MATERIAL

Document Type and Number:

WIPO Patent Application WO2003003999

Kind Code:

A3

Abstract:

A solid phannaceutical composition comprising a water-soluble bioactive material and an encapsulating material which is present in the composition in the form of continuous solid phase, and in which solid particles of the bioactive material are dispersed and encapsulated in the continuous solid phase of the encapsulating material, wherein each of the bioactive material and the encapsulating material is normally a solid at room temperature and the melting point of the encapsulating material is lower than the melting point of the bioactive material, the bioactive material being preferably a bisphosphonate, most preferably alendronate, and the encapsulating material includes an enhancer, preferably a mono- or di-glyceride, or an encapsulating surfactant, preferably, a polyoxyethylene/polyoxypropylene block copolymer having surface active properties, and a process for preparing the composition in which solid particles of the bioactive material are mixed with and dispersed in the encapsulating material which is in molten (liquid) form; and cooling the molten form of the encapsulating material to form a solid pharmaceutical composition having the solid particles of the bioactive material dispersed and encapsulated in a continuous solid phase of the encapsulating material.

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Inventors:

CLANCY MAURICE JOSEPH ANTHONY (IE)
CLUMMING K LAIN (IE)
MC CRYSTAL CONOR B (IE)

Application Number:

PCT/IB2002/003651

Publication Date:

June 19, 2003

Filing Date:

July 02, 2002

Export Citation:

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Assignee:

ELAN CORP PLC (IE)
CLANCY MAURICE JOSEPH ANTHONY (IE)
CLUMMING K LAIN (IE)
MC CRYSTAL CONOR B (IE)

International Classes:

A61K9/14; A61K9/16; A61K9/48; A61K9/50; A61K31/66; A61K31/663; A61K47/14; A61K47/34; A61P19/10; (IPC1-7): A61K9/48; A61K31/663

Domestic Patent References:

WO1999018972A1	1999-04-22
WO2000061111A1	2000-10-19
WO1997005903A2	1997-02-20
WO2001037808A1	2001-05-31
WO2000000179A1	2000-01-06
WO2001082903A1	2001-11-08

Foreign References:

EP0761208A1	1997-03-12
US4450877A	1984-05-29
EP0642786A1	1995-03-15
US5281420A	1994-01-25

Other References: