Title:
DENDRITIC CELL-MIMICKED NANOSTRUCTURE FOR APPLICATION TO CANCER IMMUNOTHERAPY, AND FABRICATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/124544
Kind Code:
A1
Abstract:
The present invention relates to a dendritic cell-mimicked nanostructure and a fabrication method therefor and, more specifically, to a nanostructure in which a shell including a cell membrane of dendritic cell-derived lipid molecules is introduced to a nanoparticle core in order to take advantage of the surface antigen-presenting ability of dendritic cells and which enables targeting without disappearance in vivo, thereby providing an effect of inducing an effective immune response.
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Inventors:
HONG JINKEE (KR)
HA SANGJUN (KR)
CHOI DAHEUI (KR)
KANG TAEGUN (KR)
KIM TAIHYUN (KR)
HA SANGJUN (KR)
CHOI DAHEUI (KR)
KANG TAEGUN (KR)
KIM TAIHYUN (KR)
Application Number:
PCT/KR2021/013746
Publication Date:
June 16, 2022
Filing Date:
October 07, 2021
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K9/51; A61K39/00; A61K41/00; A61P35/00
Foreign References:
| CN110090298A | 2019-08-06 | |||
| KR20030070454A | 2003-08-30 |
Other References:
LIU WEN-LONG, ZOU MEI-ZHEN, LIU TAO, ZENG JIN-YUE, LI XUE, YU WU-YANG, LI CHU-XIN, YE JING-JIE, SONG WEN, FENG JUN, ZHANG XIAN-ZHE: "Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055939119, DOI: 10.1038/s41467-019-11157-1
GAO WEIWEI, HU CHE-MING J., FANG RONNIE H., LUK BRIAN T., SU JING, ZHANG LIANGFANG: "Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 25, no. 26, 12 July 2013 (2013-07-12), DE , pages 3549 - 3553, XP055939153, ISSN: 0935-9648, DOI: 10.1002/adma.201300638
OCHYL LUKASZ J., MOON JAMES J.: "Dendritic Cell Membrane Vesicles for Activation and Maintenance of Antigen‐Specific T Cells", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 8, no. 4, 1 February 2019 (2019-02-01), DE , pages 1801091, XP055939175, ISSN: 2192-2640, DOI: 10.1002/adhm.201801091
GAO WEIWEI, ZHANG LIANGFANG: "Coating nanoparticles with cell membranes for targeted drug delivery", JOURNAL OF DRUG TARGETING, vol. 23, no. 7/8, 30 November 2014 (2014-11-30), GB , pages 619 - 626, XP009537290, ISSN: 1061-186X, DOI: 10.3109/1061186X.2015.1052074
HU, CHE-MING J. ET AL., NATURE, vol. 526, no. 7571, 2015, pages 118 - 12
BRIAN T. LUK ET AL., THERANOSTICS, vol. 6, no. 7, 2016, pages 1004 - 101
Q. JIANG ET AL., BIOMATERIALS, vol. 192, 2019, pages 292 - 308
GAO WEIWEI, HU CHE-MING J., FANG RONNIE H., LUK BRIAN T., SU JING, ZHANG LIANGFANG: "Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 25, no. 26, 12 July 2013 (2013-07-12), DE , pages 3549 - 3553, XP055939153, ISSN: 0935-9648, DOI: 10.1002/adma.201300638
OCHYL LUKASZ J., MOON JAMES J.: "Dendritic Cell Membrane Vesicles for Activation and Maintenance of Antigen‐Specific T Cells", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 8, no. 4, 1 February 2019 (2019-02-01), DE , pages 1801091, XP055939175, ISSN: 2192-2640, DOI: 10.1002/adhm.201801091
GAO WEIWEI, ZHANG LIANGFANG: "Coating nanoparticles with cell membranes for targeted drug delivery", JOURNAL OF DRUG TARGETING, vol. 23, no. 7/8, 30 November 2014 (2014-11-30), GB , pages 619 - 626, XP009537290, ISSN: 1061-186X, DOI: 10.3109/1061186X.2015.1052074
HU, CHE-MING J. ET AL., NATURE, vol. 526, no. 7571, 2015, pages 118 - 12
BRIAN T. LUK ET AL., THERANOSTICS, vol. 6, no. 7, 2016, pages 1004 - 101
Q. JIANG ET AL., BIOMATERIALS, vol. 192, 2019, pages 292 - 308
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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