Title:
DEVICE FOR RAPID DNA SAMPLE PROCESSING WITH INTEGRATED LIQUID HANDLING, THERMOCYCLING, AND PURIFICATION
Document Type and Number:
WIPO Patent Application WO2000066995
Kind Code:
A3
Abstract:
The present invention provides an automated device to facilitate rapid processing of sub-microliter samples using chemical or enzymatic reactions that involve liquid handling, one or more controlled temperature incubation steps (including temperature cycling), and a purification step based on molecular size discrimination. Exemplary applications include but are not limited to polymerase chain reaction (PCR), DNA sequencing applications, oligonucleotide ligation, ligase chain reaction (LCR), single nucleotide extension, exonuclease treatment, and oligonucleotide hybridization assays.
Inventors:
CAHILL PATRICK
SMITH DOUGLAS
THOMANN ULRICH
ENGELSTEIN MARCY
SMITH DOUGLAS
THOMANN ULRICH
ENGELSTEIN MARCY
Application Number:
PCT/US2000/011371
Publication Date:
July 26, 2001
Filing Date:
April 29, 2000
Export Citation:
Assignee:
GENOME THERAPEUTICS CORP (US)
International Classes:
G01N33/48; B01D61/18; B01D61/28; B01D63/02; B01J19/00; B01L3/00; C12M1/00; C12Q1/68; G01N27/447; G01N35/08; G01N37/00; C40B60/14; G01N35/00; (IPC1-7): B01L3/00; C12Q1/68; B01J19/00; B01L7/00; B01L3/02
Domestic Patent References:
| WO1999013312A1 | 1999-03-18 | |||
| WO1997048818A1 | 1997-12-24 |
Foreign References:
| US4769216A | 1988-09-06 | |||
| US5449064A | 1995-09-12 | |||
| EP0903176A2 | 1999-03-24 | |||
| US5856174A | 1999-01-05 | |||
| US5030555A | 1991-07-09 | |||
| EP0805350A1 | 1997-11-05 | |||
| EP0616218A1 | 1994-09-21 |
Download PDF:
Previous Patent: PROCESSING TECHNOLOGY FOR LCM SAMPLES
Next Patent: METHOD AND DEVICE FOR ACCELERATING AGEING OF PLASTIC SMART CARDS
Next Patent: METHOD AND DEVICE FOR ACCELERATING AGEING OF PLASTIC SMART CARDS