Title:
DIABETIC MODEL
Document Type and Number:
WIPO Patent Application WO2003019197
Kind Code:
A3
Abstract:
The invention relates to an animal e.g. rodent such as bank vole (clethrionomys glareolus) model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds for treating or preventing diabetes symptoms. The invention further relates to an assay for determining an individual's susceptibility to developing diabetes. The invention also relates to nucleic acid molecules isolated from Ljungan virus a picornavirus and to polypeptides encoded by any portion of said nucleic acid molecule.
Inventors:
NIKLASSON BO (SE)
LERNMARK AAKE (SE)
LERNMARK AAKE (SE)
Application Number:
PCT/IB2002/003957
Publication Date:
May 06, 2004
Filing Date:
August 21, 2002
Export Citation:
Assignee:
APODEMUS AB (SE)
NIKLASSON BO (SE)
LERNMARK AAKE (SE)
NIKLASSON BO (SE)
LERNMARK AAKE (SE)
International Classes:
A01K67/027; G01N33/564; G01N33/569; (IPC1-7): G01N33/569; C07K14/085; A61K39/125
Domestic Patent References:
| WO1998011133A1 | 1998-03-19 |
Other References:
NIKLASSON BO ET AL: "Could myocarditis, insulin-dependent diabetes mellitus, and Guillain-Barre syndrome be caused by one or more infectious agents carried by rodents?", EMERGING INFECTIOUS DISEASES, vol. 4, no. 2, April 1998 (1998-04-01), pages 187 - 193, XP002246824, ISSN: 1080-6040
TSUGIYASU KANDA ET AL: "Combination of OK432 and human interferon-@ for treating viral-induced diabetes mellitus in mice", EUROPEAN JOURNAL OF PHARMACOLOGY 342, 1998, pages 297 - 302, XP002246825
NIKLASSON B ET AL: "A new picornavirus isolated from bank voles (Clethrionomys glareolus).", VIROLOGY. UNITED STATES 1 MAR 1999, vol. 255, no. 1, 1 March 1999 (1999-03-01), pages 86 - 93, XP002246826, ISSN: 0042-6822
SCHOENECKER B ET AL: "Development of stereotypies and polydipsia in wild caught bank voles (Clethrionomys glareolus) and their laboratory-bred offspring. Is polydipsia a symptom of diabetes mellitus?.", APPLIED ANIMAL BEHAVIOUR SCIENCE, vol. 68, no. 4, July 2000 (2000-07-01), pages 349 - 357, XP002246827, ISSN: 0168-1591
BO NIKLASSON ET AL: "Development of Typ e 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus", EXPERIMENTAL DIAB. RES., TAYLOR & FRANCIS, 2003, XP002246828
SUSANNE JOHANSSON ET AL: "Molecular Analysis of Three Ljungan Virus Isolates Reveals a New Close-to-Root Lineage of the Picornaviridae with a Cluster of Two Unrelated 2A Proteins", JOURNAL OF VIROLOGY, vol. 76, no. 17, September 2002 (2002-09-01), pages 8920 - 8930, XP002246829
LINDBERG A M ET AL: "Phylogenetic analysis of Ljungan virus and A-2 plaque virus, new members of the Picornaviridae.", VIRUS RESEARCH. NETHERLANDS 23 APR 2002, vol. 85, no. 1, 23 April 2002 (2002-04-23), pages 61 - 70, XP002246830, ISSN: 0168-1702
TSUGIYASU KANDA ET AL: "Combination of OK432 and human interferon-@ for treating viral-induced diabetes mellitus in mice", EUROPEAN JOURNAL OF PHARMACOLOGY 342, 1998, pages 297 - 302, XP002246825
NIKLASSON B ET AL: "A new picornavirus isolated from bank voles (Clethrionomys glareolus).", VIROLOGY. UNITED STATES 1 MAR 1999, vol. 255, no. 1, 1 March 1999 (1999-03-01), pages 86 - 93, XP002246826, ISSN: 0042-6822
SCHOENECKER B ET AL: "Development of stereotypies and polydipsia in wild caught bank voles (Clethrionomys glareolus) and their laboratory-bred offspring. Is polydipsia a symptom of diabetes mellitus?.", APPLIED ANIMAL BEHAVIOUR SCIENCE, vol. 68, no. 4, July 2000 (2000-07-01), pages 349 - 357, XP002246827, ISSN: 0168-1591
BO NIKLASSON ET AL: "Development of Typ e 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus", EXPERIMENTAL DIAB. RES., TAYLOR & FRANCIS, 2003, XP002246828
SUSANNE JOHANSSON ET AL: "Molecular Analysis of Three Ljungan Virus Isolates Reveals a New Close-to-Root Lineage of the Picornaviridae with a Cluster of Two Unrelated 2A Proteins", JOURNAL OF VIROLOGY, vol. 76, no. 17, September 2002 (2002-09-01), pages 8920 - 8930, XP002246829
LINDBERG A M ET AL: "Phylogenetic analysis of Ljungan virus and A-2 plaque virus, new members of the Picornaviridae.", VIRUS RESEARCH. NETHERLANDS 23 APR 2002, vol. 85, no. 1, 23 April 2002 (2002-04-23), pages 61 - 70, XP002246830, ISSN: 0168-1702
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