Title:
DIAGNOSING AND MANAGING VENOUS THROMBOEMBOLISM AND INTRACARDIAC THROMBI USING A PROVOKED D-DIMER TEST
Document Type and Number:
WIPO Patent Application WO/2011/022054
Kind Code:
A3
Abstract:
The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention comprises the steps of: obtaining a plasma sample from said individual; determining the baseline level of D-dimer in said sample; contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin; and measuring the level of D-dimer is said sample after administering or contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin, wherein a significantly greater concentration of D-dimer after contact with a compound that catalyzes the conversion of plasminogen into plasmin than prior to contact with a compound that catalyzes the conversion of plasminogen into plasmin indicates that said individual has pulmonary embolism or venous thromboembolism.
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Inventors:
ROBINSON VINCENT J B (US)
Application Number:
PCT/US2010/002265
Publication Date:
June 23, 2011
Filing Date:
August 18, 2010
Export Citation:
Assignee:
MED COLLEGE GEORGIA RES INST (US)
ROBINSON VINCENT J B (US)
ROBINSON VINCENT J B (US)
International Classes:
C12Q1/56; G01N33/53
Foreign References:
| US6673561B1 | 2004-01-06 |
Other References:
CUSHMAN, M. ET AL.: "Fibrin fragment D-dimer and the risk of future venous thrombosis", BLOOD., vol. 101, 2003, pages 1243 - 1248, XP008152811
ROBINSON, V. J. B. ET AL.: "Latex D-dimer Signal in In Situ Femoral Vein Thrombus in Swine and Effect of Minidose Exogenous Tissue Plasminogen Activator Bolus", CHEST., vol. 127, 28 February 2005 (2005-02-28), pages 622 - 629, XP008152812
BRIMBLE, K. S. ET AL.: "Evaluation of the Combination of a Bedside D-Dimer Assay and Enzyme-Linked Immunosorbent Soluble Fibrin Assay in Patients with Suspected Venous Thromboembolism", THROMBOSIS RESEARCH., vol. 88, no. 3, 1 November 1997 (1997-11-01), pages 291 - 297, XP002408680
JOSEPH D. MILLS, MICHAEL W. MANSFIELD, AND PETER J. GRANT: "Tissue Plasminogen Activator, Fibrin D-Dimer, and Insulin Resistance in the Relatives of Patients With Premature Coronary Artery Disease", ARTERIOSCLER. THROMB. VASC. BIOL., vol. 22, 31 January 2002 (2002-01-31), pages 704 - 709, XP008152813
See also references of EP 2467495A4
ROBINSON, V. J. B. ET AL.: "Latex D-dimer Signal in In Situ Femoral Vein Thrombus in Swine and Effect of Minidose Exogenous Tissue Plasminogen Activator Bolus", CHEST., vol. 127, 28 February 2005 (2005-02-28), pages 622 - 629, XP008152812
BRIMBLE, K. S. ET AL.: "Evaluation of the Combination of a Bedside D-Dimer Assay and Enzyme-Linked Immunosorbent Soluble Fibrin Assay in Patients with Suspected Venous Thromboembolism", THROMBOSIS RESEARCH., vol. 88, no. 3, 1 November 1997 (1997-11-01), pages 291 - 297, XP002408680
JOSEPH D. MILLS, MICHAEL W. MANSFIELD, AND PETER J. GRANT: "Tissue Plasminogen Activator, Fibrin D-Dimer, and Insulin Resistance in the Relatives of Patients With Premature Coronary Artery Disease", ARTERIOSCLER. THROMB. VASC. BIOL., vol. 22, 31 January 2002 (2002-01-31), pages 704 - 709, XP008152813
See also references of EP 2467495A4
Attorney, Agent or Firm:
ADLER, Benjamin, Aaron (8011 Candle LaneHouston, TX, US)
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