Title:
DIHYDROOROTATE DEHYDROGENASE INHIBITORS FOR THE TREATMENT OF VIRAL-MEDIATED DISEASES
Document Type and Number:
WIPO Patent Application WO2001024785
Kind Code:
A3
Abstract:
Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon alpha 2, interferon alpha 8 or interferon beta , or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.
Inventors:
TAN YIN HWEE (SG)
DRISCOLL JOHN STANFORD (US)
MUI MUI SIM (SG)
DRISCOLL JOHN STANFORD (US)
MUI MUI SIM (SG)
Application Number:
PCT/US2000/026797
Publication Date:
July 11, 2002
Filing Date:
September 29, 2000
Export Citation:
Assignee:
INST OF MOLECUL & CELL BIOLOGY (SG)
TAN YIN HWEE (SG)
DRISCOLL JOHN STANFORD (US)
MUI MUI SIM (SG)
TAN YIN HWEE (SG)
DRISCOLL JOHN STANFORD (US)
MUI MUI SIM (SG)
International Classes:
G01N33/50; A61K31/00; A61K31/122; A61K31/194; A61K31/196; A61K31/365; A61K31/4184; A61K31/437; A61K31/47; A61K31/513; A61K38/21; A61K45/00; A61K45/06; A61P1/02; A61P1/16; A61P11/00; A61P25/00; A61P29/00; A61P31/14; A61P43/00; C07D215/52; C07D235/02; G01N33/15; A61K38/00; (IPC1-7): A61K31/00; A61K31/122; A61K31/196; A61K31/343; A61K31/4184; A61K31/437; A61K31/47; A61K31/4709; A61K31/473; A61K31/497; A61K31/711; A61K38/21; A61P31/14; C07D215/52
Foreign References:
| US4680299A | 1987-07-14 | |||
| EP0601191A1 | 1994-06-15 | |||
| EP0721942A1 | 1996-07-17 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 14 31 December 1998 (1998-12-31)
Download PDF: