Title:
DIRECT CELL CONVERSION-BASED METHOD FOR DIFFERENTIATION OF NEURAL STEM CELLS INTO ASTROCYTES
Document Type and Number:
WIPO Patent Application WO/2020/153687
Kind Code:
A1
Abstract:
The present invention relates to a method for efficiently differentiating neural stem cells into astrocytes and, more particularly, to a cell conversion-based method for more efficiently differentiating human neural stem cells into astrocytes that exhibit immune response suppression ability within a short period of time. Unlike a conventional method, the method for differentiating neural stem cells into astrocytes by using a differentiation medium containing a combination of several cytokines, according to the present invention, involves a shortened differentiation time and has excellent differentiation efficiency, and the differentiated astrocytes exhibit immune response suppression ability, and thus can be useful as an agent for treating various brain diseases such as degenerative neurological diseases.
Inventors:
HONG SUNG HOI (KR)
JANG AHYOUNG (KR)
CHOI KYUNG-AH (KR)
JANG AHYOUNG (KR)
CHOI KYUNG-AH (KR)
Application Number:
PCT/KR2020/000948
Publication Date:
July 30, 2020
Filing Date:
January 20, 2020
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12N5/079; A61K35/30; A61P29/00
Foreign References:
| KR20150042670A | 2015-04-21 | |||
| US20150353888A1 | 2015-12-10 | |||
| US20180306780A1 | 2018-10-25 | |||
| KR20160024126A | 2016-03-04 |
Other References:
CHANDRASEKARAN, A.: "Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research", FRONTIERS IN CELLULAR NEUROSCIENCE, 26 September 2016 (2016-09-26), XP055727507
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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