Title:
DIRECTED COMBINATORIAL COMPOUND LIBRARY AND HIGH THROUGHPUT ASSAYS FOR SCREENING SAME
Document Type and Number:
WIPO Patent Application WO1999064378
Kind Code:
A3
Abstract:
A combinatorial library comprising a predetermined collection of nucleoside peptide molecules for inhibiting the transfer of a sugar from a selected sugar nucleotide donor to a selected acceptor by a carbohydrate processing enzyme. The nucleoside peptide molecule comprises (a) a nucleoside monomer; (b) a spacer monomer coupled to the nucleoside monomer wherein the spacer monomer comprises one or more amide linked amino acid residues, or a peptidomimetic; and (c) cap monomers attached to the spacer monomer. The nucleoside peptide molecules differ from each other as to the identity of at least one element of the nucleoside monomer, spacer monomer, or cap monomer.
Inventors:
CARVER JEREMY (CA)
DENNIS JAMES (CA)
TROPPER FRANCOIS D (CA)
SAHA UTTAM (CA)
ZISER LOTHAR (CA)
DATTI ALESSANDRO (CA)
DONOVAN ROB (CA)
DENNIS JAMES (CA)
TROPPER FRANCOIS D (CA)
SAHA UTTAM (CA)
ZISER LOTHAR (CA)
DATTI ALESSANDRO (CA)
DONOVAN ROB (CA)
Application Number:
PCT/CA1999/000550
Publication Date:
September 21, 2000
Filing Date:
June 10, 1999
Export Citation:
Assignee:
GLYCODESIGN INC (CA)
CARVER JEREMY (CA)
DENNIS JAMES (CA)
TROPPER FRANCOIS D (CA)
SAHA UTTAM (CA)
ZISER LOTHAR (CA)
DATTI ALESSANDRO (CA)
DONOVAN ROB (CA)
CARVER JEREMY (CA)
DENNIS JAMES (CA)
TROPPER FRANCOIS D (CA)
SAHA UTTAM (CA)
ZISER LOTHAR (CA)
DATTI ALESSANDRO (CA)
DONOVAN ROB (CA)
International Classes:
A61K38/00; A61K45/00; C07B61/00; C07H19/06; C07H19/16; C07K9/00; C12Q1/48; (IPC1-7): C07K9/00; A61K38/14; C07B61/00; C07H19/06; C07H19/16; C12Q1/48
Domestic Patent References:
| WO1995010296A1 | 1995-04-20 | |||
| WO1995034294A1 | 1995-12-21 |
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