Title:
DISULFIDE COMPOUNDS AND ANTINEOPLASTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/1986/004898
Kind Code:
A1
Abstract:
Mitomycin derivatives represented by general formula (I), wherein X represents X1 or X2, X1 represents an alkyl group, a cycloalkyl group (optionally substituted), a pyridyl group, an unsubstituted or substituted phenyl group, a residue of an amino acid having a thiol group or a dipeptide or tripeptide residue containing the amino acid excluding the thiol group, X2 represents a group represented by formula (II), (wherein A1 represents -(CH2)m- (wherein m represents an integer of 3 to 12) or -(CH2CH2O)n-CH2CH2- (wherein n represents an integer of 1 to 5), Y, Z, R1, and R2 are the same as defined with (I), provided that A represents -(CH2)$(1,3)$- (wherein$(1,4)$represents an integer of 3 to 8) when X is X1 and A represents A1 when X ix X2, Y and Z each represents H or methyl, and one of R1 and R2 represents a carbamoyloxymethyl group and the other represents H when X is X1, and one of them represents a carbamoyloxymethyl group and the other represents H, or both are bound to each other to form an exo-methylene group (=CH2) when X is X2. These compounds are superior to known mitomycin derivatives having two methylene units between a nitrogen atom at 7-position and a SS grouping in at least one of CI value (chemotherapeutic index), reduction of side effects, and solubility in water.
Inventors:
SHIRAHATA KUNIKATSU (JP)
KASAI MASAJI (JP)
KONO MOTOMICHI (JP)
MORIMOTO MAKOTO (JP)
ASHIZAWA TADASHI (JP)
SAITO YUTAKA (JP)
KASAI MASAJI (JP)
KONO MOTOMICHI (JP)
MORIMOTO MAKOTO (JP)
ASHIZAWA TADASHI (JP)
SAITO YUTAKA (JP)
Application Number:
PCT/JP1986/000085
Publication Date:
August 28, 1986
Filing Date:
February 21, 1986
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
International Classes:
C07D487/14; C07D519/00; C07K5/06; (IPC1-7): C07D487/14; A61K31/40
Other References:
No relevant documents have been disclosed
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