Title:
DNA VACCINE ENCODING AT LEAST TWO NONSTRUCTURAL EARLY PROTEINS OF PAPILLOMAVIRUS
Document Type and Number:
WIPO Patent Application WO2004031222
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections. In particular the invention relates to nucleic acid molecules encoding E1 and/or E2 and vectors suitable for DNA vaccine delivery, and pharmaceutical compositions containing them. Methods for manufacturing said molecules, vectors and composition are also contemplated.
Inventors:
GOUGH GERALD WAYNE (GB)
ROBERTS CHRISTOPHER MICHAEL (GB)
ROBERTS CHRISTOPHER MICHAEL (GB)
Application Number:
PCT/EP2003/011158
Publication Date:
August 19, 2004
Filing Date:
October 01, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
GOUGH GERALD WAYNE (GB)
ROBERTS CHRISTOPHER MICHAEL (GB)
GOUGH GERALD WAYNE (GB)
ROBERTS CHRISTOPHER MICHAEL (GB)
International Classes:
C07K14/025; C12N15/37; A61K39/00; (IPC1-7): C07K14/025; C12N15/37; C12N15/86; A61K39/12
Domestic Patent References:
| WO2002008435A1 | 2002-01-31 | |||
| WO1997005164A1 | 1997-02-13 |
Other References:
HAN R ET AL: "Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: protective immunity induced by gene gun-mediated intracutaneous delivery but not by intramuscular injection", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 18, no. 26, July 2000 (2000-07-01), pages 2937 - 2944, XP004199086, ISSN: 0264-410X
MOORE R A ET AL: "Intraepithelial DNA immunisation with a plasmid encoding a codon optimised COPV E1 gene sequence, but not the wild-type gene sequence completely protects against mucosal challenge with infectious COPV in beagles.", VIROLOGY, vol. 304, no. 2, 20 December 2002 (2002-12-20), pages 451 - 459, XP002284938, ISSN: 0042-6822 (ISSN print)
MOORE R A ET AL: "Therapeutic immunisation with COPV early genes by epithelial DNA delivery", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 314, no. 2, 30 September 2003 (2003-09-30), pages 630 - 635, XP004462753, ISSN: 0042-6822
MOORE R A ET AL: "Intraepithelial DNA immunisation with a plasmid encoding a codon optimised COPV E1 gene sequence, but not the wild-type gene sequence completely protects against mucosal challenge with infectious COPV in beagles.", VIROLOGY, vol. 304, no. 2, 20 December 2002 (2002-12-20), pages 451 - 459, XP002284938, ISSN: 0042-6822 (ISSN print)
MOORE R A ET AL: "Therapeutic immunisation with COPV early genes by epithelial DNA delivery", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 314, no. 2, 30 September 2003 (2003-09-30), pages 630 - 635, XP004462753, ISSN: 0042-6822
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