Title:
DSP-14 DUAL-SPECIFICITY PHOSPHATASE
Document Type and Number:
WIPO Patent Application WO2001083723
Kind Code:
A3
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-14, and polypeptide variants thereof that stimulate dephosphorylation of DSP-14 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-14 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Inventors:
LUCHE RALF M (US)
WEI BO (US)
WEI BO (US)
Application Number:
PCT/US2001/014076
Publication Date:
May 02, 2002
Filing Date:
May 01, 2001
Export Citation:
Assignee:
CEPTYR INC (US)
LUCHE RALF M (US)
WEI BO (US)
LUCHE RALF M (US)
WEI BO (US)
International Classes:
C12N9/16; (IPC1-7): C12N15/52; A61K39/395; C07K16/40; C12N5/10; C12N9/16; C12N15/11; C12N15/63; C12Q1/68; G01N33/573
Domestic Patent References:
| WO1997000315A1 | 1997-01-03 | |||
| WO1997006245A1 | 1997-02-20 | |||
| WO2000055332A2 | 2000-09-21 | |||
| WO2001046394A2 | 2001-06-28 |
Other References:
NAKAMURA KOJI ET AL: "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 344, no. 3, 15 December 1999 (1999-12-15), pages 819 - 825, XP002144926, ISSN: 0264-6021
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