Title:
EXTENDED cDNAs FOR SECRETED PROTEINS
Document Type and Number:
WIPO Patent Application WO1999025825
Kind Code:
A3
Abstract:
The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.
Inventors:
BOUGUELERET LYDIE (FR)
DUCLERT AYMERIC (FR)
DUMAS MILNE EDWARDS JEAN-BAPTI (FR)
DUCLERT AYMERIC (FR)
DUMAS MILNE EDWARDS JEAN-BAPTI (FR)
Application Number:
PCT/IB1998/001862
Publication Date:
July 29, 1999
Filing Date:
November 13, 1998
Export Citation:
Assignee:
GENSET SA (FR)
BOUGUELERET LYDIE (FR)
DUCLERT AYMERIC (FR)
DUMAS MILNE EDWARDS JEAN BAPTI (FR)
BOUGUELERET LYDIE (FR)
DUCLERT AYMERIC (FR)
DUMAS MILNE EDWARDS JEAN BAPTI (FR)
International Classes:
C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N15/09; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/68; (IPC1-7): C12N15/12; C07K14/47; C07K16/18; C12Q1/68
Domestic Patent References:
| WO1999006548A2 | 1999-02-11 | |||
| WO1998045436A2 | 1998-10-15 | |||
| WO1996034981A2 | 1996-11-07 | |||
| WO1997007198A2 | 1997-02-27 |
Foreign References:
| EP0625572A1 | 1994-11-23 |
Other References:
Database EMBL, Entry HST03538 Accession number T03538 24 August 1993 97% identity with Seq.ID:134 nt.48-499
Database EMBL, Entry HSA57573 Accession number AA057573 19 September 1996 98% identity with Seq.ID:134 nt.102-746
Database EMBL, Entry HS409287 Accession number N57409 29 February 1996 100% identity with Seq.ID:134 nt.581-1041 reverse orientation
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954
LOCKHART D.J. ET AL.: "Expression monitoring by hybridization to high-density oligonucleotide arrays", BIO/TECHNOLOGY, no. 14, 14 December 1996 (1996-12-14), pages 1675 - 1680, XP002074420
Database EMBL, Entry HSA57573 Accession number AA057573 19 September 1996 98% identity with Seq.ID:134 nt.102-746
Database EMBL, Entry HS409287 Accession number N57409 29 February 1996 100% identity with Seq.ID:134 nt.581-1041 reverse orientation
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954
LOCKHART D.J. ET AL.: "Expression monitoring by hybridization to high-density oligonucleotide arrays", BIO/TECHNOLOGY, no. 14, 14 December 1996 (1996-12-14), pages 1675 - 1680, XP002074420
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