Title:
ENHANCER OF PHOTODYNAMIC EFFECT IN ALA-PDT OR ALA-PDD
Document Type and Number:
WIPO Patent Application WO/2016/204060
Kind Code:
A1
Abstract:
[Problem] To provide a pharmaceutical for enhancing the photodynamic response in ALA-PDT or ALA-PDD. [Solution] Provided is a pharmaceutical for enhancing the photodynamic response in photodynamic therapy or photodynamic diagnosis, the pharmaceutical characterized in containing ALAs and being used in combination with nobiletin or a composition containing nobiletin.
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Inventors:
ISHIZUKA MASAHIRO (JP)
NAKAGAWA HITOSHI (JP)
OTA URARA (JP)
ICHIKAWA TOMOKI (JP)
NAKAGAWA HITOSHI (JP)
OTA URARA (JP)
ICHIKAWA TOMOKI (JP)
Application Number:
PCT/JP2016/067183
Publication Date:
December 22, 2016
Filing Date:
June 09, 2016
Export Citation:
Assignee:
SBI PHARMACEUTICALS CO LTD (JP)
International Classes:
A61K31/197; A61K31/352; A61K36/75; A61K36/752; A61K41/00; A61K49/00; A61P17/00; A61P35/00; A61P43/00
Other References:
ELJAMEL, M. SAM ET AL.: "Intraoperative optical identification of pituitary adenomas", JOURNAL OF NEURO-ONCOLOGY, vol. 92, no. 3, 2009, pages 417 - 421, XP019685364, ISSN: 0167-594X
HAJ-HOSSEINI, NEDA ET AL.: "Low dose 5- aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery", PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol. 12, no. 2, 26 March 2015 (2015-03-26), pages 209 - 214, XP029237260, ISSN: 1572-1000
PECH, OLIVER ET AL.: "Long-term results of photodynamic therapy with 5-aminolevulinic acid for superficial Barrett's cancer and high-grade intraepithelial neoplasia", GASTROINTESTINAL ENDOSCOPY, vol. 62, no. 1, 2005, pages 24 - 30, XP005284946, ISSN: 0016-5107
CHEN, JIANCHU ET AL.: "Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells", BMC PHARMACOLOGY AND TOXICOLOGY, vol. 15, no. 59, 2014, pages 1 - 10, XP055337947, ISSN: 2050-6511
SUN, DAN ET AL.: "Enhancement of Photodynamic therapy induced cytotoxicity in K562 cells by genistein", SYMPOSIUM ON PHOTONICS AND OPTOELECTRONICS, May 2011 (2011-05-01), pages 408 - 411, XP031880053, ISBN: 978-1-4244-6555-2
GANDARA, L ET AL.: "The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, vol. 133, 2014, pages 55 - 64, XP028646137, ISSN: 1011-1344
HAJ-HOSSEINI, NEDA ET AL.: "Low dose 5- aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery", PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol. 12, no. 2, 26 March 2015 (2015-03-26), pages 209 - 214, XP029237260, ISSN: 1572-1000
PECH, OLIVER ET AL.: "Long-term results of photodynamic therapy with 5-aminolevulinic acid for superficial Barrett's cancer and high-grade intraepithelial neoplasia", GASTROINTESTINAL ENDOSCOPY, vol. 62, no. 1, 2005, pages 24 - 30, XP005284946, ISSN: 0016-5107
CHEN, JIANCHU ET AL.: "Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells", BMC PHARMACOLOGY AND TOXICOLOGY, vol. 15, no. 59, 2014, pages 1 - 10, XP055337947, ISSN: 2050-6511
SUN, DAN ET AL.: "Enhancement of Photodynamic therapy induced cytotoxicity in K562 cells by genistein", SYMPOSIUM ON PHOTONICS AND OPTOELECTRONICS, May 2011 (2011-05-01), pages 408 - 411, XP031880053, ISBN: 978-1-4244-6555-2
GANDARA, L ET AL.: "The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, vol. 133, 2014, pages 55 - 64, XP028646137, ISSN: 1011-1344
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
Masahiro Nanjo (JP)
Masahiro Nanjo (JP)
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