Title:
ESTER DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/004402
Kind Code:
A1
Abstract:
Compounds of the general formula (|), which exhibit selective muscarinic M¿3? receptor antagonism, little have side effects, and are suitable for administration by inhalation and useful as therapeutic agents for respiratory system diseases or the like: (|) wherein A is a group of the general formula (a¿0?) or (b¿0?): (a¿0?) (b¿0?) Ar is aryl or heteroaryl, any of which may be substituted; B?1¿ and B?2¿ are each an aliphatic hydrocarbon group; R?1¿ is fluorinated cycloalkyl; R?2¿, R?3¿ and R?4¿ are each lower alkyl, or a single bond or alkylene, any of which is bonded to B?1¿, or alternatively R?2¿ and R?3¿ may be united to form alkylene; R?5¿ and R?7¿ are each hydrogen, lower alkyl, or a single bond or alkylene, any of which is bonded to B?2¿; R?6¿ is hydrogen, lower alkyl, or N(R?8¿)R?9¿; and X?-¿ is an anion.
Inventors:
OGINO YOSHIO (JP)
KURIHARA HIDEKI (JP)
MATSUDA KENJI (JP)
NUMAZAWA TOMOSHIGE (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)
KURIHARA HIDEKI (JP)
MATSUDA KENJI (JP)
NUMAZAWA TOMOSHIGE (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)
Application Number:
PCT/JP2001/005987
Publication Date:
January 17, 2002
Filing Date:
July 10, 2001
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
OGINO YOSHIO (JP)
KURIHARA HIDEKI (JP)
MATSUDA KENJI (JP)
NUMAZAWA TOMOSHIGE (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)
OGINO YOSHIO (JP)
KURIHARA HIDEKI (JP)
MATSUDA KENJI (JP)
NUMAZAWA TOMOSHIGE (JP)
OTAKE NORIKAZU (JP)
NOGUCHI KAZUHITO (JP)
International Classes:
A61P11/00; A61P11/06; A61P27/16; A61P43/00; C07C219/10; C07C219/14; C07D205/04; C07D207/08; C07D207/12; C07D209/52; C07D211/22; C07D211/42; C07D211/46; C07D211/70; C07D239/06; C07D451/02; C07D451/06; C07D471/08; C07D471/10; C07D487/10; C07D498/10; (IPC1-7): C07C219/10; C07C219/22; C07C219/24; C07C251/08; C07C251/18; C07D211/46; C07D405/12; C07D451/02; C07D207/12; C07D207/08; C07D221/24; C07D209/52; C07D498/10; C07D471/10; C07D487/10; C07D211/22; C07D211/70; C07D295/125; C07D205/04; C07D239/06; A61K31/452; A61K31/439; A61K31/435; A61K31/4409; A61K31/403; A61K31/222; A61K31/395; A61K31/40; A61K31/5386; A61K31/438; A61K31/407; A61P11/00; A61P11/06; A61P43/00; A61P27/16; A61K31/4525; A61K31/397; A61K31/55
Domestic Patent References:
| WO1998021183A1 | 1998-05-22 |
Foreign References:
| EP0140434A2 | 1985-05-08 | |||
| FR1352332A | 1964-02-14 |
Other References:
See also references of EP 1302458A4
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (Tokyo, Tokyo, JP)
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