Title:
ESTRADIOL-CONTAINING PERCUTANEOUS ABSORPTION PREPARATIONS
Document Type and Number:
WIPO Patent Application WO/1999/053957
Kind Code:
A1
Abstract:
Percutaneous absorption preparations which contain estradiol as the active ingredient together with a base ingredient composed of N-vinylacetamide copolymers containing as the major components N-vinylacetamide and a polymerizable monomer having a COOM group (wherein M represents hydrogen, an alkali metal salt or an ammonium salt), glycerol, glycols, fillers, pH regulating agents, crosslinking agents, penetration accelerators and surfactants. These preparations liberate estradiol continuously over a prolonged period of time, little irritate the skin and are excellent in the sticking to the skin.
Inventors:
MORI MASAO (JP)
YAMA SEIJIRO (JP)
MATSUZAWA TAKAYASU (JP)
YAMA SEIJIRO (JP)
MATSUZAWA TAKAYASU (JP)
Application Number:
PCT/JP1998/001766
Publication Date:
October 28, 1999
Filing Date:
April 17, 1998
Export Citation:
Assignee:
LEAD CHEM CO LTD (JP)
MORI MASAO (JP)
YAMA SEIJIRO (JP)
MATSUZAWA TAKAYASU (JP)
MORI MASAO (JP)
YAMA SEIJIRO (JP)
MATSUZAWA TAKAYASU (JP)
International Classes:
A61K31/565; A61K47/30; A61K47/32; (IPC1-7): A61K47/30
Foreign References:
| JPH04182437A | 1992-06-30 | |||
| JPH05148145A | 1993-06-15 |
Attorney, Agent or Firm:
Hanabusa, Tsuneo (Ochanomizu Square B 6, Kandasurugadai 1-chom, Chiyoda-ku Tokyo, JP)
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