Title:
EVALUATION OF BREAST CANCER STATES AND OUTCOMES USING GENE EXPRESSION PROFILES
Document Type and Number:
WIPO Patent Application WO2004037996
Kind Code:
A3
Abstract:
The present invention relates generally to a method for evaluating and/or predicting breast cancer states and outcomes by measuring gene and metagene expression levels and integrating such data with clinical risk factors. Genes and metagenes whose expressions are correlated with a particular breast cancer risk factor or phenotype are provided using binary prediction tree modelling. Methods of using the subject genes and metagenes in diagnosis and treatment methods, as well as drug screening methods, etc are also provided. In addition, reagents, media and kits that find use in practicing the subject methods are also provided.
Inventors:
WEST MIKE (US)
NEVINS JOSEPH R (US)
HUANG ANDREW (US)
NEVINS JOSEPH R (US)
HUANG ANDREW (US)
Application Number:
PCT/US2003/033656
Publication Date:
December 29, 2004
Filing Date:
October 24, 2003
Export Citation:
Assignee:
UNIV DUKE (US)
WEST MIKE (US)
NEVINS JOSEPH R (US)
HUANG ANDREW (US)
WEST MIKE (US)
NEVINS JOSEPH R (US)
HUANG ANDREW (US)
International Classes:
G01N33/48; G06F19/00; C12N; (IPC1-7): G01N33/48; G06F19/00
Other References:
SORLIE ET AL: "Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications", PNAS, vol. 98, no. 19, 11 September 2001 (2001-09-11), pages 10869 - 10874, XP002215483
STOECKERT ET AL: "A relational schema for both array-based and SAGE gene expression experiments", BIOINFORMATICS, vol. 17, 2001, pages 300 - 308, XP001086454
FELLENBERG ET AL: "Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis", BIOINFORMATICS, vol. 18, 2002, pages 423 - 433, XP002978946
BENSON ET AL: "GenBank", NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 1 - 6, XP002967189
STOECKERT ET AL: "A relational schema for both array-based and SAGE gene expression experiments", BIOINFORMATICS, vol. 17, 2001, pages 300 - 308, XP001086454
FELLENBERG ET AL: "Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis", BIOINFORMATICS, vol. 18, 2002, pages 423 - 433, XP002978946
BENSON ET AL: "GenBank", NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 1 - 6, XP002967189
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