Title:
EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING
Document Type and Number:
WIPO Patent Application WO/2020/040840
Kind Code:
A3
Abstract:
Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
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Inventors:
JEWETT MICHAEL CHRISTOPHER (US)
LEE JOONGOO (US)
MOORE JEFFREY S (US)
SCHWIETER KENNETH E (US)
SCHWARZ KEVIN JEROME (US)
LEE JOONGOO (US)
MOORE JEFFREY S (US)
SCHWIETER KENNETH E (US)
SCHWARZ KEVIN JEROME (US)
Application Number:
PCT/US2019/035215
Publication Date:
April 30, 2020
Filing Date:
June 03, 2019
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
International Classes:
C12N15/11; C12N15/09; C12P19/34
Foreign References:
| EP1964916A1 | 2008-09-03 |
Other References:
ZHANG JINWEI ET AL.: "A flexible, scalable method for preparation of homogeneous aminoacylated tRNAs", METHODS ENZYMOL., vol. 549, 2014, pages 1 - 9, XP055709629, DOI: 10.1016/B978-0-12-801122-5.00005-2
PASSIOURA TOBY ET AL.: "Flexizyme-Mediated Genetic Reprogramming As a Tool for Noncanonical Peptide Synthesis and Drug Discovery", CHEMISTRY - A EUROPEAN JOURNAL, vol. 19, no. 21, 2013, pages 6530 - 6536, XP055709651, DOI: 10.1002/chem.201300247
PASSIOURA TOBY ET AL.: "Flexizyme-Mediated Genetic Reprogramming As a Tool for Noncanonical Peptide Synthesis and Drug Discovery", CHEMISTRY - A EUROPEAN JOURNAL, vol. 19, no. 21, 2013, pages 6530 - 6536, XP055709651, DOI: 10.1002/chem.201300247
Attorney, Agent or Firm:
MCBRIDE, M. Scott (US)
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