Title:
EXTRACELLULAR VESICLES DERIVED FROM LACTOBACILLUS BACTERIA, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/255795
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diseases caused by immune and metabolic disorders, comprising, as an active ingredient, extracellular vesicles derived from Lactobacillus bacteria. The vesicles derived from Lactobacillus bacteria, according to the present invention, spread to major organs after being absorbed into the body, move to organelles after being absorbed into cells, and then inhibit NF-κB signaling, which are crucial signals of the inflammatory response and thus can regulate same. In addition, vesicles according to the present invention activate AMPK signals under metabolic stress conditions during which ATP production is inhibited and increases the viability of cells under metabolic stress conditions, and thus are expected to be effectively used in the development of medicine, or functional food for health, and the like for alleviating, preventing, or treating diseases caused by immune and metabolic disorders.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2022/007786
Publication Date:
December 08, 2022
Filing Date:
May 31, 2022
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
A61K35/747; A23L33/135; A61K8/99; A61K9/00; A61P3/00; A61P37/00; A61Q19/00
Foreign References:
| KR20190105522A | 2019-09-17 | |||
| KR20180072589A | 2018-06-29 | |||
| KR20200053531A | 2020-05-18 | |||
| KR20180019482A | 2018-02-26 | |||
| KR20160110232A | 2016-09-21 | |||
| KR102098067B1 | 2020-04-07 | |||
| KR102257130B1 | 2021-05-28 | |||
| KR20110082481A | 2011-07-19 | |||
| KR20210072078A | 2021-06-16 | |||
| KR20210186256A |
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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