Title:
FUSED IMIDAZOLIUM DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/060803
Kind Code:
A1
Abstract:
The invention relates to novel fused imidazolium derivatives useful as drugs, particularly in the treatment of cancers, and novel intermediates for the preparation of the derivatives. Novel imidazolium derivatives fused with aromatic carbo- or hetero-cycles and characterized by being substituted at the 1- and/or 3-position with alkyl bearing -OR¿a?, -SR¿a?, or other substituent exhibit excellent antitumor activity and low toxicity, thus being useful as anticancer drugs having wide margins of safety.
Inventors:
MATSUHISA AKIRA (JP)
KINOYAMA ISAO (JP)
TOYOSHIMA AKIRA (JP)
NAKAHARA TAKAHITO (JP)
TAKEUCHI MASAHIRO (JP)
OKADA MINORU (JP)
KINOYAMA ISAO (JP)
TOYOSHIMA AKIRA (JP)
NAKAHARA TAKAHITO (JP)
TAKEUCHI MASAHIRO (JP)
OKADA MINORU (JP)
Application Number:
PCT/JP2001/001036
Publication Date:
August 23, 2001
Filing Date:
February 14, 2001
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
MATSUHISA AKIRA (JP)
KINOYAMA ISAO (JP)
TOYOSHIMA AKIRA (JP)
NAKAHARA TAKAHITO (JP)
TAKEUCHI MASAHIRO (JP)
OKADA MINORU (JP)
MATSUHISA AKIRA (JP)
KINOYAMA ISAO (JP)
TOYOSHIMA AKIRA (JP)
NAKAHARA TAKAHITO (JP)
TAKEUCHI MASAHIRO (JP)
OKADA MINORU (JP)
International Classes:
A61K31/36; A61K31/416; A61K31/4188; A61K31/424; A61K31/4245; A61K31/427; A61K31/429; A61K31/437; A61K31/4453; A61K31/4468; A61K31/454; A61K31/47; A61K31/4709; A61K31/497; A61K31/4985; A61K31/501; A61K31/5025; A61K31/506; A61K31/519; A61K31/5375; A61K31/551; A61P35/00; C07C233/41; C07C235/14; C07C237/04; C07C255/24; C07C255/25; C07C255/58; C07C259/06; C07C271/28; C07C311/37; C07C317/28; C07C323/25; C07D209/16; C07D211/58; C07D213/38; C07D213/64; C07D213/74; C07D213/89; C07D215/12; C07D233/54; C07D235/02; C07D235/14; C07D239/26; C07D241/12; C07D241/20; C07D295/13; C07D307/14; C07D317/58; C07D333/68; C07D335/06; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D405/06; C07D471/04; C07D491/048; C07D495/04; C07D498/04; C07D235/10; (IPC1-7): C07D235/02; C07D401/06; C07D403/06; C07D401/14; C07D401/12; C07D417/06; C07D413/06; C07D405/06; C07D471/04; C07D495/04; C07D498/04; C07D513/04; C07D487/04; C07D491/048; C07D213/38; C07D333/68; C07D235/14; C07D307/52; C07D209/14; C07D333/40; C07D211/58; C07D215/12; C07D295/12; C07D317/58; C07C311/39; C07C317/28; C07C323/25; C07C233/41; C07C255/58; C07C237/04; C07C235/14; A61K31/416; A61K31/4439; A61K31/497; A61K31/454; A61K31/501; A61K31/551; A61K31/427; A61K31/506; A61K31/4245; A61K31/424; A61K31/429; A61K31/4188; A61K31/4985; A61K31/519; A61K31/5025; A61K31/437; A61K31/4709; A61K31/4468; A61K31/47; A61K31/5375; A61K31/4453; A61K31/36; A61P35/00
Foreign References:
| GB1314881A | 1973-04-26 |
Other References:
KHIM.-FARM. ZH., vol. 32, no. 6, 1998, pages 10 - 11, XP002941579
J. MED. CHEM., vol. 32, no. 7, 1989, pages 1467 - 1471, XP002941580
J. MED. CHEM., vol. 39, no. 7, 1996, pages 1447 - 1451, XP002941581
J. MED. CHEM., vol. 32, no. 7, 1989, pages 1467 - 1471, XP002941580
J. MED. CHEM., vol. 39, no. 7, 1996, pages 1447 - 1451, XP002941581
Attorney, Agent or Firm:
Nagai, Shozo c/o Yamanouchi Pharmaceutical Co. (Ltd. Patent Department 17-1 Hasune 3-chome Itabashi-ku, Tokyo, JP)
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