Title:
GPib-LIPID BOND CONSTRUCT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/064743
Kind Code:
A1
Abstract:
A construct wherein a glycoprotein (GP) Ib is bonded to a lipid via a polyalkylene oxide; and a complex (GPIb lipid complex) containing this bond construct and a free lipid. This GPIb lipid complex is expected as widely applicable in practice as, for example, a substitute for platelets, drugs (preventives and remedies for vascular lesion, vascular damage, thrombosis, etc.), diagnostics for vWF deficiency, etc., biological and medicinal reagents, and reagents for screening platelet aggregation inhibitors and antithrombotic agents. Moreover, the GPIb lipid complex is highly useful as diagnostics or remedies for examining vascular damage or thrombogenetic sites. Furthermore, the GPIb lipid complex is excellent in the retention properties in the blood and can exert sustained pharmacological effects. The above-described bond construct is highly valuable as the active ingredient of the GPIb lipid complex.
Inventors:
IKEDA YASUO (JP)
SAITO HIROSHI (JP)
MUKAI HIROMICHI (JP)
MORI YOSHIYUKI (JP)
MURATA MITSURU (JP)
SAITO HIROSHI (JP)
MUKAI HIROMICHI (JP)
MORI YOSHIYUKI (JP)
MURATA MITSURU (JP)
Application Number:
PCT/JP2001/001635
Publication Date:
September 07, 2001
Filing Date:
March 02, 2001
Export Citation:
Assignee:
WELFIDE CORP (JP)
IKEDA YASUO (JP)
SAITO HIROSHI (JP)
MUKAI HIROMICHI (JP)
MORI YOSHIYUKI (JP)
MURATA MITSURU (JP)
IKEDA YASUO (JP)
SAITO HIROSHI (JP)
MUKAI HIROMICHI (JP)
MORI YOSHIYUKI (JP)
MURATA MITSURU (JP)
International Classes:
A61K47/48; A61K49/00; A61K49/14; A61K51/08; A61P7/02; A61P7/04; A61P9/00; A61P29/00; C07K14/705; A61K38/00; (IPC1-7): C07K14/475; A61K38/14; A61K47/34; A61K9/127; A61K47/24; A61K47/26; A61K47/14; A61K47/28; A61K45/00; A61K49/06; A61K49/04; A61K49/14; A61K51/08; A61P7/02; A61P7/04; A61P9/00; A61P29/00
Domestic Patent References:
| WO1999058694A1 | 1999-11-18 |
Foreign References:
| EP0894807A1 | 1999-02-03 |
Other References:
ZALIPSKY S. ET AL.: "Poly (ethylene glycol)-grafted liposomes with oligopeptide or oligosaccharide ligands appended to the termini of the polymer chains", BIOCONJUGATE CHEMISTRY, vol. 8, no. 2, 1997, pages 111 - 118, XP002942108
ZALIPSKY S. ET AL.: "Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes", BIOCONJUGATE CHEMISTRY, vol. 4, no. 4, 1993, pages 296 - 299, XP002942109
WEBB M.S. ET AL.: "Comparison of different hydrophobic anchors conjugated to poly (ethylene glycol): effects on the pharmacokinetics of liposomal vincristine", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1372, no. 2, 1998, pages 272 - 282, XP002942110
See also references of EP 1262490A4
ZALIPSKY S. ET AL.: "Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes", BIOCONJUGATE CHEMISTRY, vol. 4, no. 4, 1993, pages 296 - 299, XP002942109
WEBB M.S. ET AL.: "Comparison of different hydrophobic anchors conjugated to poly (ethylene glycol): effects on the pharmacokinetics of liposomal vincristine", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1372, no. 2, 1998, pages 272 - 282, XP002942110
See also references of EP 1262490A4
Attorney, Agent or Firm:
Takashima, Hajime (Fushimimachi 4-chome Chuo-ku Osaka-shi Osaka, JP)
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