Title:
GASTROINTESTINAL STROMAL TUMOR TARGET DEPDC5 AND APPLICATION THEREOF IN DIAGNOSIS AND TREATMENT
Document Type and Number:
WIPO Patent Application WO/2020/143424
Kind Code:
A1
Abstract:
The present invention provides a gastrointestinal stromal tumor target DEPDC5 and an application thereof in diagnosis and treatment. Specifically, provided is a use of a gene, mRNA, cDNA, or a protein of DEPDC5, or a detection reagent thereof for (i) serving as markers used to detect primary gastrointestinal stromal tumors or advanced gastrointestinal stromal tumors and/or (ii) preparing diagnostic reagents or kits used to detect primary gastrointestinal stromal tumors or advanced gastrointestinal stromal tumors. Further provided is an application of the DEPDC5 gene, a protein thereof, or an agonist thereof in the treatment of gastrointestinal stromal tumors.
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Inventors:
WANG YUEXIANG (CN)
PANG YUZHI (CN)
PANG YUZHI (CN)
Application Number:
PCT/CN2019/126730
Publication Date:
July 16, 2020
Filing Date:
December 19, 2019
Export Citation:
Assignee:
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C12Q1/68; A61K38/00; A61P35/00
Foreign References:
| EP2770325A1 | 2014-08-27 | |||
| EP2770325A1 | 2014-08-27 |
Other References:
YUKI MIZUNO, SHU SHIMADA, YOSHIMITSU AKIYAMA, SHUICHI WATANABE, TOMOMI AIDA, KOSUKE OGAWA, HIROAKI ONO, YUSUKE MITSUNORI, DAISUKE : "DEPDC5 Deficiency Contributes to Resistance to Leucine Starvation via P62 Accumulation in Hepatocellular Carcinoma", SCIENTIFIC REPORT, vol. 8, no. 1, 106, 8 January 2018 (2018-01-08), pages 1 - 11, XP055718896, DOI: 10.1038/s41598-017-18323-9
N. MA,X. ZHANG,F. YU,P. GAO,Q. FAN,L. LIU ,D. LIU: "Role of IFN-λs , IFN-λs related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease", JOURNAL OF VIRAL HEPATITIS, vol. 21, no. 7, 20 February 2014 (2014-02-20), pages e29 - e-38, XP055718900, ISSN: 1352-0504, DOI: 10.1111/jvh.12235
N. MA,X. ZHANG,F. YU,P. GAO,Q. FAN,L. LIU ,D. LIU: "Role of IFN-λs , IFN-λs related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease", JOURNAL OF VIRAL HEPATITIS, vol. 21, no. 7, 20 February 2014 (2014-02-20), pages e29 - e-38, XP055718900, ISSN: 1352-0504, DOI: 10.1111/jvh.12235
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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