Title:
GENE AND PROTEIN INVOLVED IN LIVER REGENERATION
Document Type and Number:
WIPO Patent Application WO2000003013
Kind Code:
A3
Abstract:
The present invention relates to a gene involved in regeneration processes of the liver and comprising a nucleotide sequence which is at least 70 % homologous to the sequence of figure 1 or the sequence of figure 6, or the complementary strand thereof, for use in the design of PCR probes for detecting nucleotide sequences in a source material, which nucleotide sequences represent genes corresponding with the gene sequence of figure 1 or the sequence of figure 6; protein encoded by said gene for use in diagnosis of liver regeneration and/or liver cell proliferation; and antibodies directed against this protein, a PCR primer comprising at least part of said gene as a probe, a single stranded nucleotide sequence being at least in part complementary to the messenger RNA transcribed from said gene as a probe an expression vector and a host cell comprising said nucleotide sequence, for use in a method for detecting the occurrence of liver cell proliferation in a subject.
Inventors:
CHAMULEAU ROBERT ANTOINE FRANC (NL)
GROENINK MARTIJN (NL)
VAN DER VLIET HENDRIK NIELS (NL)
LEEGWATER ADAM CORNELIS JOZEF (NL)
GROENINK MARTIJN (NL)
VAN DER VLIET HENDRIK NIELS (NL)
LEEGWATER ADAM CORNELIS JOZEF (NL)
Application Number:
PCT/EP1999/004938
Publication Date:
February 24, 2000
Filing Date:
July 12, 1999
Export Citation:
Assignee:
AMSTERDAM MOLECULAR THERAPEUTICS BV (NL)
CHAMULEAU ROBERT ANTOINE FRANC (NL)
GROENINK MARTIJN (NL)
VLIET HENDRIK NIELS V D (NL)
LEEGWATER ADAM CORNELIS JOZEF (NL)
CHAMULEAU ROBERT ANTOINE FRANC (NL)
GROENINK MARTIJN (NL)
VLIET HENDRIK NIELS V D (NL)
LEEGWATER ADAM CORNELIS JOZEF (NL)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C12N15/12; A01K67/027; C07K14/47; C07K16/18; C12Q1/68
Domestic Patent References:
| WO1996039540A1 | 1996-12-12 |
Other References:
MARRA M ET AL.: "Sugano mouse liver mlia Mus musculus cDNA clone 1431407 similar to apolipoprotein A-IV (accession number AA987093)", EMBL SEQUENCE DATABASE, 29 May 1998 (1998-05-29), Heidelberg, Germany, XP002095461
DATABASE R60U083 EMBL, Heidelberg, Germany; 3 June 1999 (1999-06-03), HU P AND ROE B A: "Homo sapiens chromosome 11 clone 442e11 from RPCI11", XP002125969
DATABASE R60U083 EMBL, Heidelberg, Germany; 3 June 1999 (1999-06-03), HU P AND ROE B A: "Homo sapiens chromosome 11 clone 442e11 from RPCI11", XP002125969
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