Title:
GENE THERAPY OF ALZHEIMER'S DISEASE BY DELIVERY OF AN ENCODED APOLIPOPROTEIN E
Document Type and Number:
WIPO Patent Application WO2000023587
Kind Code:
A3
Abstract:
The invention relates to Alzheimer's disease and more specifically to gene therapy and prevention of Alzheimer's disease. The invention provides a gene delivery or gene therapy vehicle and methods for its use in therapy and prevention of dementia's such as Alzheimer's disease whereby a functional ApoE gene or a functional equivalent thereof is introduced or delivered into human or humanised cells such as progenitor cells for example monocytes or glialcells.
Inventors:
VERLINDEN STEFAN FREDERIK FRAN (NL)
VAN BEKKUM DIRK WILLEM (NL)
VAN BEKKUM DIRK WILLEM (NL)
Application Number:
PCT/NL1999/000638
Publication Date:
August 03, 2000
Filing Date:
October 15, 1999
Export Citation:
Assignee:
INTROGENE BV (NL)
VERLINDEN STEFAN FREDERIK FRAN (NL)
BEKKUM DIRK WILLEM VAN (NL)
VERLINDEN STEFAN FREDERIK FRAN (NL)
BEKKUM DIRK WILLEM VAN (NL)
International Classes:
A61K35/30; A61K38/17; A61K48/00; A61P25/28; C07K14/775; C12N5/10; C12N15/12; (IPC1-7): C12N15/12; A61K35/30; A61K48/00; A61P25/28; C12N5/10
Domestic Patent References:
| WO1996014837A1 | 1996-05-23 | |||
| WO1997016458A1 | 1997-05-09 |
Other References:
KAPLITT, MICHAEL ET AL: "Apolipoprotein E, A-beta- amyloid, and the molecular pathology of Alzheimer's disease: Therapeutic implications.", RELKIN, N. R. [EDITOR];KHACHATURIAN, Z. [EDITOR]; GANDY, S. [EDITOR]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, (1996) VOL. 802, PP. 42-49. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; APOLIPOPROTEIN E GENOTYPING IN ALZHEIMER'S DISEASE. PUBLISHER: N, XP002100573
DATABASE CHEMICAL ABSTRACTS FILE SERVER STN KARLSRUHE; FAZIO ET AL: "Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis", XP002100575
BARGER ET AL: "MICROGLIAL ACTIVATION BY ALZHEIMER AMYLOID PRECURSOR PROTEIN AND MODULATION BY APOLIPOPROTEIN E", NATURE, vol. 388, 28 August 1997 (1997-08-28), pages 878 - 881, XP002093548
EGLITIS ET AL: "HEMATOPOIETIC CELLS DIFFERENTIATE INTO BOTH MICROGLIA AND MACROGLIA IN THE BRAINS OF ADULT MICE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 94, 1997, pages 4080 - 4085, XP002100574
DATABASE CHEMICAL ABSTRACTS FILE SERVER STN KARLSRUHE; FAZIO ET AL: "Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis", XP002100575
BARGER ET AL: "MICROGLIAL ACTIVATION BY ALZHEIMER AMYLOID PRECURSOR PROTEIN AND MODULATION BY APOLIPOPROTEIN E", NATURE, vol. 388, 28 August 1997 (1997-08-28), pages 878 - 881, XP002093548
EGLITIS ET AL: "HEMATOPOIETIC CELLS DIFFERENTIATE INTO BOTH MICROGLIA AND MACROGLIA IN THE BRAINS OF ADULT MICE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 94, 1997, pages 4080 - 4085, XP002100574
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