Title:
GENETIC MAKE-UP MODIFIES CANCER OUTCOME
Document Type and Number:
WIPO Patent Application WO/2012/018613
Kind Code:
A3
Abstract:
A frequent SNP A259G (K87E) genotype switch in the MMP8 gene in has been found to modify the clinical behavior of cancers. The modification varies based on the patient's genotype for the SNP, and whether homozygous or heterozygous. One particular genotype for this SNP leads to more aggressive tumor behavior and worst clinical outcome than the others.
Inventors:
XING MICHAEL MINGZHAO (US)
Application Number:
PCT/US2011/045340
Publication Date:
May 24, 2012
Filing Date:
July 26, 2011
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
XING MICHAEL MINGZHAO (US)
XING MICHAEL MINGZHAO (US)
International Classes:
C12Q1/68; C12N15/57
Other References:
GONZALEZ-ARRIAGA, P. ET AL.: "Polymorphism +17 C/G in matrix metalloprotea se MMP8 decreases lung cancer risk", BMC CANCER, vol. 8, 19 December 2008 (2008-12-19), pages 378, XP021048956, DOI: doi:10.1186/1471-2407-8-378
NAN, H. ET AL.: "Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk", CANCER EPIDEMIOL BIOMARKERS PREV., vol. 17, 8 December 2008 (2008-12-08), pages 3551 - 3 557
DECOCK, J. ET AL.: "Association of matrix metalloproteinase-8 gene variati on with breast cancer prognosis", CANCER RESEARCH, vol. 67, 1 November 2007 (2007-11-01), pages 10214 - 10221
WANG, H. ET AL.: "Functionally significant SNP MMP8 promoter haplotypes an d preterm premature rupture of membranes (PPROM)", HUMAN MOLECULAR GENETICS, vol. 13, no. 21, 14 September 2004 (2004-09-14), pages 2659 - 2669
NAN, H. ET AL.: "Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk", CANCER EPIDEMIOL BIOMARKERS PREV., vol. 17, 8 December 2008 (2008-12-08), pages 3551 - 3 557
DECOCK, J. ET AL.: "Association of matrix metalloproteinase-8 gene variati on with breast cancer prognosis", CANCER RESEARCH, vol. 67, 1 November 2007 (2007-11-01), pages 10214 - 10221
WANG, H. ET AL.: "Functionally significant SNP MMP8 promoter haplotypes an d preterm premature rupture of membranes (PPROM)", HUMAN MOLECULAR GENETICS, vol. 13, no. 21, 14 September 2004 (2004-09-14), pages 2659 - 2669
Attorney, Agent or Firm:
KAGAN, Sarah A. (1100 13th Street, N.W.,Suite 120, Washington District of Columbia, US)
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