Title:
GENETICALLY ENGINEERED CELL LINES AND SYSTEMS FOR PROPAGATING VARICELLA ZOSTER VIRUS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003095623
Kind Code:
A3
Abstract:
The present invention provides genetically engineered cell lines, recombinant vectors, and vaccines. The present invention also provides methods for generating an in vitro system for Varicella zoster virus (VZV), and the in vitro systems generated by these methods. The present invention further provides methods for reactivating VZV, and VZV reactivated by these methods. Finally, the present invention provides a method of screening for an agent for treating VZV infection.
Inventors:
CHEN JASON J
GERSHON ANNE A
ZHU ZHENGLUN
SILVERSTEIN S
GERSHON MICHAEL D
GERSHON ANNE A
ZHU ZHENGLUN
SILVERSTEIN S
GERSHON MICHAEL D
Application Number:
PCT/US2003/014825
Publication Date:
September 02, 2004
Filing Date:
May 12, 2003
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
C07K14/035; C07K14/04; C12N7/04; (IPC1-7): C12Q1/68
Foreign References:
| US6302685B1 | 2001-10-16 |
Other References:
ZHU ET AL: "Infection of Cells by Varicella Zoster Virus: Inhibition of Viral Entry by Mannose 6-Phosphate and Heparin", PNAS, vol. 92, April 1995 (1995-04-01), pages 3546 - 3550, XP002978730
LOWRY ET AL: "Investigation of the pathogenesis of varicella-zoster virus infection in Guinea pigs by using polymerase chain reaction", J. OF INFECTIOUS DISEASES, vol. 167, 1993, pages 78 - 83, XP002978773
MORIUCHI ET AL: "Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0", J. OF VIROLOGY, vol. 66, no. 12, December 1992 (1992-12-01), pages 7303 - 7308, XP002978771
MORIUCHI ET AL: "Varicella-zoster virus (VZV) open reading frame 61 protein transactivates VZV gene promoters and enhances the infectivity of VZV DNA", J. OF VIROLOGY, vol. 67, no. 7, July 1993 (1993-07-01), pages 4290 - 4295, XP002978772
GABEL ET AL: "Varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation", J. OF VIROLOGY, vol. 63, no. 10, October 1989 (1989-10-01), pages 4264 - 4276, XP002978770
COHEN ET AL: "Varicella-Zoster Virus ORF61 Deletion Mutants Replicate in Cell Culture, but a Mutant with Stop Codons in ORF61 Reverts to Wild-Type virus", VIROLOGY, vol. 246, 1998, pages 306 - 316, XP004445758
STEVENSON ET AL: "Characterization of the varicella-zoster virus gene 61 protein", J. OF GENERAL VIROLOGY, vol. 73, 1992, pages 521 - 530, XP002978738
KYLE ET AL: "Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer", J. OF BIOLOGICAL CHEMISTRY, vol. 263, no. 31, 5 November 1988 (1988-11-05), pages 16230 - 16235, XP002978731
LOWRY ET AL: "Investigation of the pathogenesis of varicella-zoster virus infection in Guinea pigs by using polymerase chain reaction", J. OF INFECTIOUS DISEASES, vol. 167, 1993, pages 78 - 83, XP002978773
MORIUCHI ET AL: "Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0", J. OF VIROLOGY, vol. 66, no. 12, December 1992 (1992-12-01), pages 7303 - 7308, XP002978771
MORIUCHI ET AL: "Varicella-zoster virus (VZV) open reading frame 61 protein transactivates VZV gene promoters and enhances the infectivity of VZV DNA", J. OF VIROLOGY, vol. 67, no. 7, July 1993 (1993-07-01), pages 4290 - 4295, XP002978772
GABEL ET AL: "Varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation", J. OF VIROLOGY, vol. 63, no. 10, October 1989 (1989-10-01), pages 4264 - 4276, XP002978770
COHEN ET AL: "Varicella-Zoster Virus ORF61 Deletion Mutants Replicate in Cell Culture, but a Mutant with Stop Codons in ORF61 Reverts to Wild-Type virus", VIROLOGY, vol. 246, 1998, pages 306 - 316, XP004445758
STEVENSON ET AL: "Characterization of the varicella-zoster virus gene 61 protein", J. OF GENERAL VIROLOGY, vol. 73, 1992, pages 521 - 530, XP002978738
KYLE ET AL: "Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer", J. OF BIOLOGICAL CHEMISTRY, vol. 263, no. 31, 5 November 1988 (1988-11-05), pages 16230 - 16235, XP002978731
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