GLUCOPYRANOSYLOXY BENZYLBENZENE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THE PREPARATION OF THE DERIVATIVES

Title:

GLUCOPYRANOSYLOXY BENZYLBENZENE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THE PREPARATION OF THE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2001/068660

Kind Code:

A1

Abstract:

Glucopyranosyloxybenzylbenzene derivatives of the general formula (I) and salts thereof, which exhibit excellent human SGLT2 inhibiting activity and are useful as preventive or therapeutic drugs for diabetes, obesity and so on; and intermediates for the preparation of the derivatives wherein R?1¿ is hydrogen or hydroxylated lower alkyl; R?2¿ is lower alkyl, lower alkoxy, lower alkylthio, hydroxylated lower alkyl, hydroxylated lower alkoxy, hydroxylated lower alkylthio, or the like.

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Inventors:

FUJIKURA HIDEKI (JP)
FUSHIMI NOBUHIKO (JP)
NISHIMURA TOSHIHIRO (JP)
TATANI KAZUYA (JP)
KATSUNO KENJI (JP)
HIRATOCHI MASAHIRO (JP)
TOKUTAKE YOSHIKI (JP)
ISAJI MASAYUKI (JP)

Application Number:

PCT/JP2001/002041

Publication Date:

September 20, 2001

Filing Date:

March 15, 2001

Export Citation:

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Assignee:

KISSEI PHARMACEUTICAL (JP)
FUJIKURA HIDEKI (JP)
FUSHIMI NOBUHIKO (JP)
NISHIMURA TOSHIHIRO (JP)
TATANI KAZUYA (JP)
KATSUNO KENJI (JP)
HIRATOCHI MASAHIRO (JP)
TOKUTAKE YOSHIKI (JP)
ISAJI MASAYUKI (JP)

International Classes:

A61K31/7034; A61P3/04; A61P3/10; A61P43/00; C07C39/04; C07C69/16; C07C69/18; C07C69/78; C07C323/18; C07H15/203; (IPC1-7): C07H15/203; A61K31/7034; A61P43/00; A61P3/10; A61P3/04; C07C69/78; C07C69/16; C07C69/18; C07C323/18; C07C39/15; C07C43/23

Foreign References:

US5232946A

1993-08-03

Other References:

AKIRA OKU ET AL.: "Antidiabetic effect of T-1095, an inhibitor Na+-glucose cotransporter, in neonatally streptozotocin-treated rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 391, no. 1-2, 10 March 2000 (2000-03-10), pages 183 - 192, XP002942080
See also references of EP 1270584A4

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