Title:
GROUP TRANSFER METHOD FOR SELECTIVE MODIFICATION OF TARGET PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/088291
Kind Code:
A1
Abstract:
Provided are a group transfer method for the selective modification of a target protein and the use thereof. According to the group transfer method for the selective modification of a target protein, a target protein is modified efficiently and selectively on the basis of a group transfer reaction of a sulfur salt center. A cell immunofluorescence imaging experiment carried out on the basis of the method proves that the transfer reaction selectivity provided by means of the above-mentioned modification method can be carried out on the surface of a cell membrane, thereby realizing imaging of a cell membrane pattern.
Inventors:
LI ZIGANG (CN)
YIN FENG (CN)
WANG YUENA (CN)
ZHAO RONGTONG (CN)
WAN CHUAN (CN)
WANG DONGYUAN (CN)
YIN FENG (CN)
WANG YUENA (CN)
ZHAO RONGTONG (CN)
WAN CHUAN (CN)
WANG DONGYUAN (CN)
Application Number:
PCT/CN2020/129303
Publication Date:
May 05, 2022
Filing Date:
November 17, 2020
Export Citation:
Assignee:
UNIV PEKING SHENZHEN GRADUATE SCHOOL (CN)
SHENZHEN BAY LABORATORY PINGSHAN TRANSLATIONAL MEDICINE CENTER (CN)
SHENZHEN BAY LABORATORY PINGSHAN TRANSLATIONAL MEDICINE CENTER (CN)
International Classes:
C07K1/13; A61K31/506; A61P35/00; C07K14/705; C07K14/71; C07K14/82; C09K11/06; C12N9/12; G01N21/64
Domestic Patent References:
| WO2019178604A1 | 2019-09-19 |
Foreign References:
| CN110769822A | 2020-02-07 | |||
| CN111372585A | 2020-07-03 | |||
| CN110997710A | 2020-04-10 |
Other References:
LUO YUN-XING ,ZHAO FU-KUN ,LUO GUI-MIN ,YUAN ZHONG-YI: "Research and Development of S-Adenosyl-L-Methionine", INDUSTRIAL MICROBIOLOGY, vol. 36, no. 1, 30 March 2006 (2006-03-30), pages 54 - 59, XP055927019
CAO JIA-XUE,ZHANG HONG-PING,DU LI-XIN: "Influence of Environmental Factors on DNA Methylation", HEREDITAS, vol. 35, no. 7, 10 April 2013 (2013-04-10), pages 839 - 846, XP055927020, ISSN: 0253-9772, DOI: 10.3724/SP.J.1005.2013.00839
RYAN LISTER, MATTIA PELIZZOLA, ROBERT H. DOWEN, R. DAVID HAWKINS, GARY HON, JULIAN TONTI-FILIPPINI, JOSEPH R. NERY, LEONARD LEE, Z: "Human DNA methylomes at base resolution show widespread epigenomic differences", NATURE, vol. 462, no. 7271, 19 November 2009 (2009-11-19), pages 315 - 322, XP055076298, ISSN: 00280836, DOI: 10.1038/nature08514
CAO JIA-XUE,ZHANG HONG-PING,DU LI-XIN: "Influence of Environmental Factors on DNA Methylation", HEREDITAS, vol. 35, no. 7, 10 April 2013 (2013-04-10), pages 839 - 846, XP055927020, ISSN: 0253-9772, DOI: 10.3724/SP.J.1005.2013.00839
RYAN LISTER, MATTIA PELIZZOLA, ROBERT H. DOWEN, R. DAVID HAWKINS, GARY HON, JULIAN TONTI-FILIPPINI, JOSEPH R. NERY, LEONARD LEE, Z: "Human DNA methylomes at base resolution show widespread epigenomic differences", NATURE, vol. 462, no. 7271, 19 November 2009 (2009-11-19), pages 315 - 322, XP055076298, ISSN: 00280836, DOI: 10.1038/nature08514
Attorney, Agent or Firm:
SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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