Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/170830
Kind Code:
A1
Abstract:
Provided is a compound having an MAGL-inhibiting effect, and anticipated to be useful as a prophylactic or therapeutic agent for neurodegenerative diseases (for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injuries, glaucoma, multiple sclerosis, and the like), anxiety disorders, pain (for example, inflammatory pain, cancer pain, neurological pain, and the like), epilepsy, melancholia, and the like.
The present invention relates to the compound represented by formula (I), or a salt thereof:
[Each symbol in the formula is as described in the specification]
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Inventors:
IKEDA SHUHEI (JP)
SUGIYAMA HIDEYUKI (JP)
AIDA JUMPEI (JP)
TOKUHARA HIDEKAZU (JP)
OKAWA TOMOHIRO (JP)
OGURO YUYA (JP)
NAKAMURA MINORU (JP)
MURAKAMI MASATAKA (JP)
SUGIYAMA HIDEYUKI (JP)
AIDA JUMPEI (JP)
TOKUHARA HIDEKAZU (JP)
OKAWA TOMOHIRO (JP)
OGURO YUYA (JP)
NAKAMURA MINORU (JP)
MURAKAMI MASATAKA (JP)
Application Number:
PCT/JP2017/013169
Publication Date:
October 05, 2017
Filing Date:
March 30, 2017
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D487/10; A61K31/407; A61K31/4184; A61K31/422; A61K31/423; A61K31/424; A61K31/427; A61K31/428; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/537; A61K31/5386; A61P21/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D498/10; C12N9/18
Domestic Patent References:
| WO2015046193A1 | 2015-04-02 | |||
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NEUROCHEMICAL RESEARCH (NEUROCHEM. RES., vol. 36, 2011, pages 1520 - 1525
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NEUROBIOL. DIS., vol. 15, 2004, pages 601 - 609
BEHAVIOURAL BRAIN RESEARCH (BEHAV. BRAIN RES., vol. 252, pages 10 - 17,2013
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza, 5th ed.", vol. 13-19
THE CHEMICAL SOCIETY OF JAPAN: "Shin Jikken Kagaku Kouza", vol. 14-15
L. F. TIETZE; TH. EICHER: "Fine Organic Chemistry, Revised 2nd Edition", NANKODO
HIDEO TOGO: "Organic Name Reactions, the Reaction Mechanism and Essence", KODANSHA
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC.
JIE JACK LI: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", OXFORD UNIVERSITY
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER JAPAN
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC., article "Strategic Applications of Named Reactions in Organic Synthesis (translated by Kiyoshi Tomioka, Kagakudojin"
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis, 4th ed.", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
THE CHEMICAL SOCIETY OF JAPAN: "Shin Jikken Kagaku Kouza", vol. 14, pages: 251 - 253
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza, 4th ed.", vol. 19, pages: 273 - 274
"Development of Pharmaceutical Products", MOLECULE DESIGN, vol. 7, 1990, pages 163 - 198
SCIENCE, vol. 294, 2001, pages 1871 - 1875
MOLECULAR NEUROBIOLOGY (MOL. NEUROBIOL, vol. 41, 2010, pages 115 - 128
NEURON, vol. 53, 2007, pages 337 - 351
NATURE REVIEWS NEUROLOGY (NAT. REV. NEUROL., vol. 6, 2010, pages 193 - 201
CHEMISTRY AND PHYSICS OF LIPIDS (CHEM PHYS LIPIDS, vol. 121, 2002, pages 149 - 158
CELL REPORT (CELL REP., vol. 1, 2012, pages 617 - 623
BIOCHEMICAL PHARMACOLOGY (BIOCHEM. PHARMCOL., vol. 50, 1995, pages 83 - 90
MOLECULAR PHARMACOLOGY (MOL. PHARMACOL., vol. 34, 1988, pages 605 - 613
NEUROSCIENCE LETTERS (NEUROSCI. LETT., vol. 396, 2006, pages 113 - 116
JOURNAL OF ALZHEIMER'S DISEASE (J. ALZHEIMERS. DIS., vol. 30, 2012, pages 439 - 459
NEUROSCIENCE, vol. 178, 2011, pages 159 - 168
ANNALS OF NEUROLOGY (ANN. NEUROL., vol. 57, 2005, pages 168 - 175
SCIENCE, vol. 334, 2011, pages 809 - 813
NEUROBIOLOGY OF DISEASE (NEUROBIOL. DIS., vol. 15, 2004, pages 601 - 609
EUROPEAN JOURNAL OF PHARMACOLOGY (EUR. J. PHARMACOL., vol. 542, 2006, pages 100 - 105
BRAIN, vol. 132, 2009, pages 3152 - 3164
BRAIN RESEARCH (BRAIN RES., vol. 1390, 2011, pages 126 - 141
NATURE, vol. 413, 2001, pages 527 - 531
EXPERIMENTAL EYE RESEARCH (EXP. EYE RES., vol. 87, 2008, pages 106 - 114
BEHAVIOURAL BRAIN RESEARCH (BEHAV. BRAIN RES., vol. 252, 17 October 2013 (2013-10-17)
BRITISH JOURNAL OF PHARMACOLOGY, vol. 150, 2007, pages 693 - 701
PHARMACOLOGICAL RESEARCH (PHARMACOL. RES., vol. 64, 2011, pages 60 - 67
NATURE MEDICINE (NATURE MED., vol. 16, 2010, pages 413 - 419
NEUROCHEMICAL RESEARCH (NEUROCHEM. RES., vol. 36, 2011, pages 1520 - 1525
NEUROPSYCHOPHARMACOLOGY, vol. 39, 2014, pages 1763 - 1776
JOURNAL OF HEADACHE AND PAIN, vol. 15, no. 14, 2014
BRAIN RESEARCH, vol. 1298, 2009, pages 13 - 23
BRAIN RESEARCH, vol. 1474, 2012, pages 91 - 99
NEUROBIOL. DIS., vol. 15, 2004, pages 601 - 609
BEHAVIOURAL BRAIN RESEARCH (BEHAV. BRAIN RES., vol. 252, pages 10 - 17,2013
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza, 5th ed.", vol. 13-19
THE CHEMICAL SOCIETY OF JAPAN: "Shin Jikken Kagaku Kouza", vol. 14-15
L. F. TIETZE; TH. EICHER: "Fine Organic Chemistry, Revised 2nd Edition", NANKODO
HIDEO TOGO: "Organic Name Reactions, the Reaction Mechanism and Essence", KODANSHA
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC.
JIE JACK LI: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", OXFORD UNIVERSITY
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER JAPAN
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC., article "Strategic Applications of Named Reactions in Organic Synthesis (translated by Kiyoshi Tomioka, Kagakudojin"
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis, 4th ed.", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
THE CHEMICAL SOCIETY OF JAPAN: "Shin Jikken Kagaku Kouza", vol. 14, pages: 251 - 253
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza, 4th ed.", vol. 19, pages: 273 - 274
"Development of Pharmaceutical Products", MOLECULE DESIGN, vol. 7, 1990, pages 163 - 198
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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