HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TYROSINE KINASES

Title:

HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TYROSINE KINASES

Document Type and Number:

WIPO Patent Application WO2001025238

Kind Code:

A3

Abstract:

Disclosed are novel compounds of formula (I) wherein Ar>1<, R>a<, R>4<, R>5<, X and Y are defined below, which are useful as inhibitors of certain protein tyrosina kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of formula (I).

Inventors:

SNOW ROGER JOHN
CARDOZO MARIO GUSTAVO
GOLDBERG DANIEL
HAMMACH ABDELHAKIM
MORWICK TINA
MOSS NEIL
PATEL USHA R
PROKOPOWICZ ANTHONY S III
TAKAHASHI HIDENORI
TSCHANTZ MATT AARON
WANG XIAO-JUN

Application Number:

PCT/US2000/027444

Publication Date:

October 25, 2001

Filing Date:

October 05, 2000

Export Citation:

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Assignee:

BOEHRINGER INGELHEIM PHARMA (US)

International Classes:

A61K31/444; A61K31/4545; A61K31/4745; A61K31/496; A61K31/5377; A61P1/04; A61P3/10; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P41/00; A61P43/00; C07D217/24; C07D235/30; C07D471/04; C07D491/20; C07D513/04; C07D519/00; (IPC1-7): C07D471/04; C07D513/04; C07D498/04; A61K31/437; A61K31/4355; A61P35/00; C07D217/24

Domestic Patent References:

WO1999024035A1

1999-05-20

Foreign References:

DE2732951A1	1979-02-08
US4176184A	1979-11-27
EP0322746A1	1989-07-05
US5646153A	1997-07-08

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