HETEROCYCLIC DERIVATIVE AND MEDICINE

WIPO Patent Application WO/1996/007641

A1

A medicine containing a compound represented by general formula (I) or a salt thereof as the active ingredient, having an excellent activity of inhibiting neuron necrosis, and being useful as a remedy for cerebrovascular disorder, wherein R1 represents aryl or heteroaryl; R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino or phenyl; R3 and R4 represent each hydrogen or alkyl, or R3 and R4 are combined with the adjacent nitrogen atom to represent a 5- to 7-membered cyclic amino group NR3R4; A represents C2-C10 alkylene; W represents O, S or (CH)n (wherein CH may be substituted by alkyl, and n represents 0, 1 or 2); and X, Y and Z represent each independently CH (wherein H may be replaced by alkyl) or N, provided the case where all of X, Y and Z are CH at the same time is excepted.

CHOKAI SHOICHI (JP)
UKAI YOJIRO (JP)
AOKI TOMIYOSI (JP)
IDEGUCHI KYOICHI (JP)

PCT/JP1995/001792

March 14, 1996

September 08, 1995

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NIPPON SHINYAKU CO LTD (JP)
CHOKAI SHOICHI (JP)
UKAI YOJIRO (JP)
AOKI TOMIYOSI (JP)
IDEGUCHI KYOICHI (JP)

A61K9/08; A61K9/20; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/444; A61K31/4453; A61K31/495; A61K31/506; A61K31/505; A61K31/53; A61P9/10; A61P25/28; A61P43/00; C07D213/63; C07D213/64; C07D239/32; C07D239/34; C07D239/38; C07D239/52; C07D239/56; C07D251/16; C07D251/22; C07D401/04; C07D401/12; C07D401/14; C07D409/04; C07D409/12; (IPC1-7): C07D213/64; C07D239/38; C07D251/22; C07D401/12; C07D409/12; A61K31/44; A61K31/505; A61K31/53

JPH0649688B2

1994-06-29

SCI. PHARM., 1980, Vol. 48, R. WINTERSTEIGER, pages 68-78.

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