Title:
HETERODIMERIC IMMUNOGLOBULIN CONSTRUCTS AND PREPARATION METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/059502
Kind Code:
A1
Abstract:
Provided is a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target molecules and are more potent in the treatment of complex diseases.
Inventors:
LIU JIAWANG (CN)
SONG NANMENG (CN)
YANG DONGGE (CN)
YANG YAPING (CN)
KIM MAENGSUP (CN)
SONG NANMENG (CN)
YANG DONGGE (CN)
YANG YAPING (CN)
KIM MAENGSUP (CN)
Application Number:
PCT/CN2017/104044
Publication Date:
April 05, 2018
Filing Date:
September 28, 2017
Export Citation:
Assignee:
BEIJING HANMI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/00; A61K39/395; A61P35/00; A61P37/02; C12N15/13
Domestic Patent References:
| WO2013063702A1 | 2013-05-10 | |||
| WO2012058768A1 | 2012-05-10 | |||
| WO2013157954A1 | 2013-10-24 | |||
| WO2013157953A1 | 2013-10-24 | |||
| WO2010121766A1 | 2010-10-28 | |||
| WO2014049003A1 | 2014-04-03 | |||
| WO1996027011A1 | 1996-09-06 |
Other References:
See also references of EP 3504234A4
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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