HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS

Title:

HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS

Document Type and Number:

WIPO Patent Application WO2000064874

Kind Code:

A3

Abstract:

The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.

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Inventors:

FRENETTE RICHARD (CA)
FRIESEN RICHARD (CA)
GIRARD MARIO (CA)
GIRARD YVES (CA)
GODBOUT CEDRICKX (CA)
GUAY DANIEL (CA)
HAMEL PIERRE (CA)
PERRIER HELENE (CA)

Application Number:

PCT/CA2000/000427

Publication Date:

February 15, 2001

Filing Date:

April 19, 2000

Export Citation:

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Assignee:

MERCK FROSST CANADA INC (CA)
FRENETTE RICHARD (CA)
FRIESEN RICHARD (CA)
GIRARD MARIO (CA)
GIRARD YVES (CA)
GODBOUT CEDRICKX (CA)
GUAY DANIEL (CA)
HAMEL PIERRE (CA)
PERRIER HELENE (CA)

International Classes:

A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D213/64; C07D213/76; C07D213/79; C07D213/89; C07D405/14; C07D409/14; C07D417/14; (IPC1-7): C07D213/89; C07D213/64; C07D409/14; C07D417/14; C07D213/79; C07D213/76; C07D405/14; A61K31/4427; A61P11/00

Domestic Patent References:

WO1995035281A1	1995-12-28
WO1997022586A1	1997-06-26

Foreign References:

US5622977A

1997-04-22

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