Title:
HISTIDINE PHOSPHATASE INTERACTING PROTEIN WITH 180KD
Document Type and Number:
WIPO Patent Application WO2003006493
Kind Code:
A3
Abstract:
PHPIP-180 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PHPIP-180 polypeptides and polynucleotides in diagnostic assays.
Inventors:
KELLNER RONALD (DE)
HOCK BJOERN (DE)
HOCK BJOERN (DE)
Application Number:
PCT/EP2002/007728
Publication Date:
October 02, 2003
Filing Date:
July 11, 2002
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
KELLNER RONALD (DE)
HOCK BJOERN (DE)
KELLNER RONALD (DE)
HOCK BJOERN (DE)
International Classes:
G01N33/50; C07K14/47; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; G01N33/15; G01N33/531; (IPC1-7): C07K14/47; C07K16/18; C12N15/12; C12N15/62; G01N33/50
Domestic Patent References:
| WO2002081629A2 | 2002-10-17 |
Other References:
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XVITHE COMPLETE SEQUENCES OF 150 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", NEW YORK TIMES, NEW YORK,NY, US, vol. 7, 2000, pages 65 - 73, XP000923011
APPERSON MICHELLE L II SOO MOON ET AL: "Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family.", JOURNAL OF NEUROSCIENCE, vol. 16, no. 21, 1996, pages 6839 - 6852, XP002247309, ISSN: 0270-6474
STRACK STEFAN ET AL: "Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 33, 18 August 2000 (2000-08-18), pages 25061 - 25064, XP002247310, ISSN: 0021-9258
WALIKONIS RANDALL S ET AL: "Densin-180 forms a ternary complex with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin.", JOURNAL OF NEUROSCIENCE, vol. 21, no. 2, 15 January 2001 (2001-01-15), pages 423 - 433, XP002247311, ISSN: 0270-6474
IZAWA ICHIRO ET AL: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 7, 15 February 2002 (2002-02-15), February 15, 2002, pages 5345 - 5350, XP002247312, ISSN: 0021-9258
APPERSON MICHELLE L II SOO MOON ET AL: "Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family.", JOURNAL OF NEUROSCIENCE, vol. 16, no. 21, 1996, pages 6839 - 6852, XP002247309, ISSN: 0270-6474
STRACK STEFAN ET AL: "Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 33, 18 August 2000 (2000-08-18), pages 25061 - 25064, XP002247310, ISSN: 0021-9258
WALIKONIS RANDALL S ET AL: "Densin-180 forms a ternary complex with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin.", JOURNAL OF NEUROSCIENCE, vol. 21, no. 2, 15 January 2001 (2001-01-15), pages 423 - 433, XP002247311, ISSN: 0270-6474
IZAWA ICHIRO ET AL: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 7, 15 February 2002 (2002-02-15), February 15, 2002, pages 5345 - 5350, XP002247312, ISSN: 0021-9258
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