Title:
HUMAN ADHESION MOLECULE OCCLUDIN
Document Type and Number:
WIPO Patent Application WO/1997/032982
Kind Code:
A1
Abstract:
The invention provides the total structures of mammalian homologues of occludin as a constitutive protein of tight junctions (TJ). Human, canine and mouse occluding genes have been analysed by conducting a polymerase chain reaction based on the sequence found around a neural apoptosis inhibitory gene. Further it has been confirmed that occludin is a constitutive protein of TJ by preparing the antibody and conducting immunofluorescent cell staining.
Inventors:
TSUKITA SHOICHIRO (JP)
Application Number:
PCT/JP1997/000665
Publication Date:
September 12, 1997
Filing Date:
March 05, 1997
Export Citation:
Assignee:
EISAI CO LTD (JP)
TSUKITA SHOICHIRO (JP)
TSUKITA SHOICHIRO (JP)
International Classes:
C07K14/47; C07K14/705; C07K16/18; C07K16/28; C12N1/21; C12N15/12; A61K48/00; (IPC1-7): C12N15/12; C12N15/63; C07K14/435; C12N1/21; C12P21/02; C12Q1/68; C07K16/18; C12P21/08; A61K38/17; G01N33/53
Other References:
CELL, 80, (Jan. 1995), NATALIE ROY et al., "The Gene for Neural Apoptosis Inhibitory Protein is Partially Deleted in Individuals With Spinal Muscular Atrophy", p. 167-178.
J. CELL BIOL., 133(1), (Apr. 1996), YUHKO ANDO-AKATSUKA et al., "Interspecies Diversity of the Occludin Sequence: cDNA Cloning of Human, Mouse, Dog and Rat-Kangaroo Homologues", p. 43-47.
J. CELL. BIOL., 123(6), (1993), MIKIO FURUSE et al., "Occludin: A Novel Integral Membrane Protein Localizing at Tight Junctions", p. 1777-1788.
See also references of EP 0831148A4
J. CELL BIOL., 133(1), (Apr. 1996), YUHKO ANDO-AKATSUKA et al., "Interspecies Diversity of the Occludin Sequence: cDNA Cloning of Human, Mouse, Dog and Rat-Kangaroo Homologues", p. 43-47.
J. CELL. BIOL., 123(6), (1993), MIKIO FURUSE et al., "Occludin: A Novel Integral Membrane Protein Localizing at Tight Junctions", p. 1777-1788.
See also references of EP 0831148A4
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