Title:
HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1
Document Type and Number:
WIPO Patent Application WO2007067992
Kind Code:
A9
Abstract:
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
Inventors:
VISTICA CYNTHIA A (US)
HOLMES ERIC H (US)
BRAMS PETER (US)
WITTE ALISON (US)
CARDARELLI JOSEPHINE M (US)
HOLMES ERIC H (US)
BRAMS PETER (US)
WITTE ALISON (US)
CARDARELLI JOSEPHINE M (US)
Application Number:
PCT/US2006/061817
Publication Date:
July 26, 2007
Filing Date:
December 08, 2006
Export Citation:
Assignee:
MEDAREX INC (US)
VISTICA CYNTHIA A (US)
HOLMES ERIC H (US)
BRAMS PETER (US)
WITTE ALISON (US)
CARDARELLI JOSEPHINE M (US)
VISTICA CYNTHIA A (US)
HOLMES ERIC H (US)
BRAMS PETER (US)
WITTE ALISON (US)
CARDARELLI JOSEPHINE M (US)
International Classes:
C07K16/00
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