Title:
HUMANIZED ANTIBODIES AGAINST OX40, METHOD FOR PREPARING THE SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/119793
Kind Code:
A1
Abstract:
Provided are humanized antibodies against tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as OX40 and CD134. Also provided are the methods of hybridoma generation, the nucleic acid molecules encoding the anti-OX40 antibodies, expression vectors and host cells used for the expression of anti-OX40 antibodies. Further provided are the methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies provide a very potent agent for the treatment of multiple cancers via modulating human immune function.
Inventors:
ZHENG YONG (CN)
YANG BAOTIAN (CN)
LI JING (CN)
YANG BAOTIAN (CN)
LI JING (CN)
Application Number:
PCT/CN2019/125251
Publication Date:
June 18, 2020
Filing Date:
December 13, 2019
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
A61K39/395; C07K16/28; A61P35/00; C12N15/09
Domestic Patent References:
| WO2013142300A2 | 2013-09-26 | |||
| WO2014148895A1 | 2014-09-25 |
Foreign References:
| CN102216332A | 2011-10-12 | |||
| CN102134276A | 2011-07-27 | |||
| CN108350053A | 2018-07-31 |
Other References:
WEINBERG, A.D. ET AL.: "Science gone translational:the OX40 agonist story", IMMUNOL REV., vol. 244, no. 1, 30 November 2011 (2011-11-30), pages 218 - 231, XP002739167, DOI: 10.1111/j.1600-065X.2011.01069.x
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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