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Title:
HUMANIZED GPC3 ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/171100
Kind Code:
A1
Abstract:
Provided is a humanized antibody or antigen-binding fragment that specifically binds to GPC3. The antibody or antigen-binding fragment has high affinity with GPC3 protein, and can be used in the preparation of drugs for treating tumors and the like. Also provided are a nucleic acid molecule encoding the humanized GPC3 antibody or antigen-binding fragment, an expression vector, a host cell, and a method for preparing the antibody or antigen-binding fragment. Also provided are an immunoconjugate comprising same, a chimeric antigen receptor, an immunocompetent cell, a multispecific molecule, and a pharmaceutical composition. Also provided are a method for detecting GPC3, and a method for treating various GPC3-related disorders including hepatocellular carcinoma.

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Inventors:
GE HU (CN)
YOU SHUMEI (CN)
Application Number:
PCT/CN2022/075588
Publication Date:
August 18, 2022
Filing Date:
February 09, 2022
Export Citation:
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Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
A61K39/395; C07K16/18; A61P35/00; C12N15/09; C12P21/08; G01N33/53; G01N33/574
Domestic Patent References:
WO2020017479A12020-01-23
Foreign References:
CN112390886A2021-02-23
CN101068836A2007-11-07
CN104871003A2015-08-26
CN106459959A2017-02-22
CN108164600A2018-06-15
US20190046659A12019-02-14
CN102046200A2011-05-04
CN109988240A2019-07-09
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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