Title:
HYPOXIA-REGULATED PROMOTER AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/181983
Kind Code:
A1
Abstract:
A CAR structure containing hypoxia-regulated promoter, an expression vector, a CAR-T cell and an application thereof, as well as a method for enhancing the ability of the CAR-T cell in secreting IFN-γ and/or IL-2 factors under an anaerobic environment and a method for improving the killing ability of the CAR-T cell under the anaerobic environment. The CAR structure contains the hypoxia-controllable promoter, and the hypoxia-controllable promoter is composed of a Hif1a regulatory element and a mini-promoter. The number of repetitions of the Hif1a regulatory element is 3-5. The CAR structure may be used for targeted therapy of tumors.
Inventors:
ZHANG WEI (CN)
CHEN JUN (CN)
QI YANAN (CN)
XU YANMIN (CN)
ZHAO WENXU (CN)
HUANG XIA (CN)
ZHAO YONGCHUN (CN)
CHEN JUN (CN)
QI YANAN (CN)
XU YANMIN (CN)
ZHAO WENXU (CN)
HUANG XIA (CN)
ZHAO YONGCHUN (CN)
Application Number:
PCT/CN2020/076429
Publication Date:
September 17, 2020
Filing Date:
February 24, 2020
Export Citation:
Assignee:
CHONGQING PREC BIOTECH COMPANY LIMITED (CN)
International Classes:
C12N15/113; A61K48/00; A61P35/00; C07K16/28; C12N5/10; C12N15/62; C12N15/85
Domestic Patent References:
| WO2018213332A1 | 2018-11-22 |
Foreign References:
| CN101200732A | 2008-06-18 | |||
| CN106399318A | 2017-02-15 | |||
| CN102618577A | 2012-08-01 |
Other References:
See also references of EP 3922721A4
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (CN)
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