IDENTIFICATION OF KINASE INHIBITORS - SUNESIS PHARMACEUTICALS INC

Title:

IDENTIFICATION OF KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005034840

Kind Code:

A8

Abstract:

The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using Tethering to identify inhibitors preferentially targeting the inactive conformation.

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Inventors:

PRESCOTT JOHN C (US)
BRAISTED ANDREW

Application Number:

PCT/US2003/029870

Publication Date:

April 20, 2006

Filing Date:

September 17, 2003

Export Citation:

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Assignee:

SUNESIS PHARMACEUTICALS INC (US)
MORROW JOELLE (US)
PRESCOTT JOHN C (US)

International Classes:

C12Q1/48; G01N33/68; (IPC1-7): A61K

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