Title:
IMIDAZOLE-CONTAINING CONDENSED RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2022/222963
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I), a stereoisomer, tautomer, isotope marker, nitrogen oxide, solvate, polymorph, pharmaceutically acceptable salt or prodrug thereof, a preparation method therefor, and a pharmaceutical composition comprising same. The compound is an NK-3 receptor antagonist, which can be used for preventing and/or treating depression, anxiety disorders, psychosis, schizophrenia, psychiatric disorders, bipolar disorders, cognitive disorders, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorders, pain, convulsions, obesity, inflammatory diseases, vomiting, preeclampsia, airway-related diseases, reproductive disorders, contraception and sex hormone-dependent diseases, gynecological disease-related diseases, and climacteric syndrome-related diseases.
Inventors:
SONG YUNLONG (CN)
SHEN GUANGYUAN (CN)
LIU PENG (CN)
LI MANHUA (CN)
JIN LEI (CN)
WANG GUOCHENG (CN)
MIAO XINYUAN (CN)
HUANG YUE (CN)
SHEN GUANGYUAN (CN)
LIU PENG (CN)
LI MANHUA (CN)
JIN LEI (CN)
WANG GUOCHENG (CN)
MIAO XINYUAN (CN)
HUANG YUE (CN)
Application Number:
PCT/CN2022/087947
Publication Date:
October 27, 2022
Filing Date:
April 20, 2022
Export Citation:
Assignee:
CHANGCHUN GENESCIENCE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/4985; A61P25/00; A61P29/00
Foreign References:
| CN102906093A | 2013-01-30 | |||
| CN107405347A | 2017-11-28 | |||
| CN101686989A | 2010-03-31 | |||
| CN101568542A | 2009-10-28 | |||
| CN103906750A | 2014-07-02 | |||
| CN111278827A | 2020-06-12 | |||
| CN202110432744A | 2021-04-21 |
Other References:
DATABASE REGISTRY 25 October 2011 (2011-10-25), ANONYMOUS : "-Methanone, (4-fluorophenyl)[3-[2-(4-fluorophenyl)-4-thiazolyl]-5,6- dihydroimidazo[1,5-a]pyrazin-7(8H)-yl]-(CA INDEX NAME)", XP055978842, retrieved from STN Database accession no. 1338374-72-3
ELIEL, E.WILEN, S.: "Stereo chemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
T. HIGUCHIANDV. STELLA: "A.C.S. Symposium Series", vol. 14, 1987, PERGAMON PRESS, article "Pro-drugsas Novel Delivery Systems"
J. RAUTIO ET AL.: "Prodrugs: Designand Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
S. J. HECKER ET AL.: "Prodrugs of Phosphatesand Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345
SYN. COMM., vol. 7, 1977, pages 509 - 514
BI°C HEM, vol. 11, 1972, pages 942 - 944
ELIEL, E.WILEN, S.: "Stereo chemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
T. HIGUCHIANDV. STELLA: "A.C.S. Symposium Series", vol. 14, 1987, PERGAMON PRESS, article "Pro-drugsas Novel Delivery Systems"
J. RAUTIO ET AL.: "Prodrugs: Designand Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
S. J. HECKER ET AL.: "Prodrugs of Phosphatesand Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345
SYN. COMM., vol. 7, 1977, pages 509 - 514
BI°C HEM, vol. 11, 1972, pages 942 - 944
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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