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Title:
IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY
Document Type and Number:
WIPO Patent Application WO/2017/114497
Kind Code:
A1
Abstract:
Provided are the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.

Inventors:
MOTZ GREGORY (US)
MAVRAKIAS KONSTANTINOS JOHN (US)
LIU JINBIAO (CN)
LIU LEI (CN)
ZHENG QIANGANG (CN)
XUN GUOLIANG (CN)
XIAO QITAO (CN)
Application Number:
PCT/CN2016/113612
Publication Date:
July 06, 2017
Filing Date:
December 30, 2016
Export Citation:
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Assignee:
NOVARTIS AG (CH)
UNIV PENNSYLVANIA (US)
MOTZ GREGORY (US)
MAVRAKIAS KONSTANTINOS JOHN (US)
LIU JINBIAO (CN)
LIU LEI (CN)
ZHENG QIANGANG (CN)
XUN GUOLIANG (CN)
XIAO QITAO (CN)
International Classes:
C12N5/0783; C07D295/00; C12N15/113
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See also references of EP 3397756A4
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