Title:
IMMUNOENHANCING SALMONELLA STRAIN FOR TREATMENT OF CANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/106866
Kind Code:
A1
Abstract:
The present invention relates to a DNA construct including: a gene encoding a flagellin protein; and a gene encoding an immunoenhancer (adjuvant) protein. For effective cancer therapy by selectively killing only cancer cells, an attenuated Salmonella strain according to the present disclosure is designed to produce immunogenic substances in cancer tissue to induce a strong anti-cancer immune response, whereby tumor sizes in metastatic cancers as well as primary cancers can be significantly inhibited. Thus, the strain can be advantageously used in a prophylactic or therapeutic composition for improving survival rates.
Inventors:
MIN JUNG-JOON (KR)
HONG YEONGJIN (KR)
RHEE JOON HAENG (KR)
YOU SUNG-HWAN (KR)
HONG YEONGJIN (KR)
RHEE JOON HAENG (KR)
YOU SUNG-HWAN (KR)
Application Number:
PCT/KR2023/018120
Publication Date:
May 23, 2024
Filing Date:
November 13, 2023
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C12N15/74; A61K38/16; A61K39/112; A61K39/39; A61K45/06; A61P35/00; A61P35/04; C07K14/195
Domestic Patent References:
| WO2019199994A1 | 2019-10-17 | |||
| WO2020110154A1 | 2020-06-04 |
Foreign References:
| KR20220063113A | 2022-05-17 | |||
| KR20210111770A | 2021-09-13 | |||
| KR20190082227A | 2019-07-09 |
Other References:
ZHANG YING; TAN WENZHI; SULTONOVA RUKHSORA D.; NGUYEN DINH-HUY; ZHENG JIN HAI; YOU SUNG-HWAN; RHEE JOON HAENG; KIM SO-YOUNG; KHIM : "Synergistic cancer immunotherapy utilizing programmed Salmonella typhimurium secreting heterologous flagellin B conjugated to interleukin-15 proteins", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 298, 27 April 2023 (2023-04-27), AMSTERDAM, NL , XP087319941, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2023.122135
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
Download PDF: